Giuffrida Michelle A, Brown Dorothy Cimino, Ellenberg Susan S, Farrar John T
J Am Vet Med Assoc. 2018 May 1;252(9):1073-1083. doi: 10.2460/javma.252.9.1073.
OBJECTIVE To describe development and initial psychometric testing of an owner-reported questionnaire designed to standardize measurement of general quality of life (QOL) in dogs with cancer. DESIGN Key-informant interviews, questionnaire development, and field trial. SAMPLE Owners of 25 dogs with cancer for item development and pretesting and owners of 90 dogs with cancer for reliability and validity testing. PROCEDURES Standard methods for development and testing of questionnaire instruments intended to measure subjective states were used. Items were generated, selected, scaled, and pretested for content, meaning, and readability. Response items were evaluated with exploratory factor analysis and by assessing internal consistency (Cronbach α) and convergence with global QOL as determined with a visual analog scale. Preliminary tests of stability and responsiveness were performed. RESULTS The final questionnaire-which was named the Canine Owner-Reported Quality of Life (CORQ) questionnaire-contained 17 items related to observable behaviors commonly used by owners to evaluate QOL in their dogs. Several items pertaining to physical symptoms performed poorly and were omitted. The 17 items were assigned to 4 factors-vitality, companionship, pain, and mobility-on the basis of the items they contained. The CORQ questionnaire and its factors had high internal consistency (Cronbach α = 0.68 to 0.90) and moderate to strong correlations (r = 0.49 to 0.71) with global QOL as measured on a visual analog scale. Preliminary testing indicated good test-retest reliability and responsiveness to improvements in overall QOL. CONCLUSIONS AND CLINICAL RELEVANCE The CORQ questionnaire was a valid, reliable owner-reported questionnaire that measured general QOL in dogs with cancer and showed promise as a clinical trial outcome measure for quantifying changes in individual dog QOL occurring in response to cancer treatment and progression.
目的 描述一份由主人报告的问卷的开发过程及初步心理测量测试，该问卷旨在规范对患癌犬总体生活质量（QOL）的测量。 设计 关键信息提供者访谈、问卷开发和现场试验。 样本 25只患癌犬的主人参与项目开发和预测试，90只患癌犬的主人参与信效度测试。 程序 采用测量主观状态的问卷工具开发和测试的标准方法。生成、选择、缩放项目，并对其内容、含义和可读性进行预测试。通过探索性因素分析、评估内部一致性（Cronbach α）以及与视觉模拟量表确定的总体生活质量的收敛性来评估回答项目。进行了稳定性和反应性的初步测试。 结果 最终问卷——名为犬主人报告生活质量（CORQ）问卷——包含17个与主人通常用于评估其犬生活质量的可观察行为相关的项目。几个与身体症状相关的项目表现不佳并被省略。根据所含项目，这17个项目被分为4个因素——活力、陪伴、疼痛和活动能力。CORQ问卷及其因素具有较高内部一致性（Cronbach α = 0.68至0.90），与视觉模拟量表测量的总体生活质量具有中度至强相关性（r = 0.49至0.71）。初步测试表明重测信度良好，对总体生活质量的改善有反应性。 结论及临床意义 CORQ问卷是一份有效、可靠的由主人报告的问卷，可测量患癌犬的总体生活质量，并有望作为临床试验结局指标，用于量化个体犬生活质量因癌症治疗和进展而发生的变化。
