Wingate D L, Pearce E A, Hutton M, Dand A, Thompson H H, Wünsch E
Gut. 1978 Jul;19(7):593-601. doi: 10.1136/gut.19.7.593.
The effects on gastrointestinal myoelectric activity of infused pentagastrin, cholecystokinin (CCK), and secretin at physiological doses were studied in live dogs with implanted serosal electrodes during 56 six-hour studies. Pentagastrin dose-dependently increased gastric and duodenal slow-wave frequencies; secretin and CCK did not. Pentagastrin and CCK diminished the incidence of fasting migrating myoelectric complexes (MMCs), but MMCs were abolished only in the proximal small intestine. Pentagastrin infusion was not reflected in an increased number of spikes, whereas CCK induced a dose-dependent increase in jejunal spike activity. Secretin dose-dependently decreased duodenal and jejunal spike incidence without a marked effect on MMC incidence. Analysis of patterns of spike activity showed significant dose-dependent changes with all three peptides. The different effects of pentagastrin and CCK on spike activity in these studies may have been a consequence of pentagastrin-stimulated gastric acid secretion. None of the three peptides produced a pattern of myoelectric activity which closely resembled that seen on feeding; since, unlike food, all three peptides had little or no effect on the distal small intestine, it seems unlikely that combinations of these peptides are responsible for the change induced by food. The failure of these peptides to abolish fasting patterns in the distal intestine suggests a possible mechanism for some types of post-vagotomy dysfunction.
在56项为期6小时的研究中，使用植入浆膜电极的活犬，研究了生理剂量的五肽胃泌素、胆囊收缩素（CCK）和促胰液素对胃肠肌电活动的影响。五肽胃泌素剂量依赖性地增加胃和十二指肠的慢波频率；促胰液素和CCK则无此作用。五肽胃泌素和CCK减少了空腹移行性肌电复合波（MMC）的发生率，但仅在近端小肠中MMC被消除。五肽胃泌素输注并未导致锋电位数量增加，而CCK则诱导空肠锋电位活动呈剂量依赖性增加。促胰液素剂量依赖性地降低十二指肠和空肠的锋电位发生率，而对MMC发生率无明显影响。锋电位活动模式分析显示，所有三种肽均有显著的剂量依赖性变化。在这些研究中，五肽胃泌素和CCK对锋电位活动的不同影响可能是五肽胃泌素刺激胃酸分泌的结果。这三种肽均未产生与进食时相似的肌电活动模式；由于与食物不同，这三种肽对远端小肠几乎没有或没有影响，因此这些肽的组合似乎不太可能是食物引起变化的原因。这些肽未能消除远端肠道的空腹模式，提示了某些类型迷走神经切断术后功能障碍的一种可能机制。
