Jia Yuanyuan, Qi Deyi, Wang Tiantian, Zhang Yuyao, Chen Xufeng, Deng Huihua, Meng Dianhuai
Rehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
School of Biological Science & Medical Engineering, Southeast University, Nanjing, 211189, Jiangsu, China.
Heliyon. 2024 May 3;10(9):e30636. doi: 10.1016/j.heliyon.2024.e30636. eCollection 2024 May 15.
Numerous research works have investigated the potential impact of endocrine hormones on the severity of COVID-19-related pneumonia in individuals. However, there are few studies on the effect of pre-onset neuroendocrine hormones on the prognosis of COVID-19 patients. This study looked into the prognostic value of pre-onset hair hormone levels in COVID-19 infected individuals. This study included 27 patients with COVID-19 and collected patient information and laboratory indicators. The hormone levels in hair were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Within 28 days, 63 % of the patients in this study passed away. With 28-day mortality as the outcome index, urea nitrogen, CURB-65 score and pneumonia severity score (PSI) of 2 groups were statistically significant ( < 0.05). Among all hormone levels detected in hair, only progesterone level was substantially correlated negatively with COVID-19 patients' 28-day mortality( < 0.05). The level of progesterone in hair was substantially adversely connected with the death rate at 28 days of COVID-19 patients, according to correlation and logistic regression analysis( < 0.05). Among patients with COVID-19 pneumonia, hair progesterone levels were strongly associated with 28-day mortality, which emphasizes hair progesterone's importance as a prognostic factor.
众多研究工作调查了内分泌激素对个体中新冠病毒相关肺炎严重程度的潜在影响。然而，关于发病前神经内分泌激素对新冠病毒患者预后影响的研究较少。本研究探讨了发病前头发激素水平对新冠病毒感染个体的预后价值。本研究纳入了27例新冠病毒患者，并收集了患者信息和实验室指标。头发中的激素水平通过液相色谱-串联质谱法（LC-MS/MS）测定。在28天内，本研究中63%的患者死亡。以28天死亡率作为结局指标，两组的尿素氮、CURB-65评分和肺炎严重程度评分（PSI）具有统计学意义（P<0.05）。在头发中检测到的所有激素水平中，只有孕酮水平与新冠病毒患者的28天死亡率呈显著负相关（P<0.05）。根据相关性和逻辑回归分析，头发中的孕酮水平与新冠病毒患者28天的死亡率呈显著负相关（P<0.05）。在新冠病毒肺炎患者中，头发孕酮水平与28天死亡率密切相关，这强调了头发孕酮作为预后因素的重要性。
