Hadisi Negin, Abedi Hadi, Shokoohi Majid, Tasdemir Seval, Mamikhani S Hahriyar, Meshgi S Hahla, Zolfagharzadeh Arian, Roshangar Leila
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahar Bagher-al-Olum General Hospital, Ahar, Iran.
Cell J. 2022 Apr;24(4):182-187. doi: 10.22074/cellj.2022.8079. Epub 2022 Apr 27.
COVID-19 is an infectious disease that has become pandemic with a high mortality rate. This study aims to provide new insight into the relations between SARS-CoV-2 and the Endocrine system.
In this cross-sectional study, we have hospitalized 60 patients with a positive SARA-CoV-2 PCR test. The information of complete blood count and endocrine hormones was obtained when the patients were admitted to the hospital or for a maximum of 4 days onset the hospitalization.
Of 60 patients with COVID-19, forty-four (73.33%) had at least one abnormality mean item >×3. In total, 26 (43.33%), 21 (35%), 18 (30%), 13 (21.67%), 31 (51.67%), 12 (20%), 30 (50%), 25 (41.67%) patients having estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone, testosterone, cortisol and thyroid stimulating hormone (TSH) abnormal test results, respectively. There was no change in creatinine levels. FSH has shown drastic changes in both sexes' intensity (F: 769, P<0.0001). Although TSH had many abnormalities in women, analysis has shown no significant P value (P=0.4558). Furthermore, prolactin and testosterone mean level in men and the estradiol mean level in women have shown no significant P value (P=0.2077, P=0.1446, P=0.1351, respectively).
Results suggest that COVID-19 affects directly or non-directly glands and related hormones.
新型冠状病毒肺炎（COVID-19）是一种已成为大流行且死亡率很高的传染病。本研究旨在为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与内分泌系统之间的关系提供新的见解。
在这项横断面研究中，我们收治了60例SARS-CoV-2聚合酶链反应（PCR）检测呈阳性的患者。全血细胞计数和内分泌激素信息在患者入院时或入院后最多4天内获取。
在60例COVID-19患者中，44例（73.33%）至少有一项异常（平均项目>×3）。总共有26例（43.33%）、21例（35%）、18例（30%）、13例（21.67%）、31例（51.67%）、12例（20%）、30例（50%）、25例（41.67%）患者的雌二醇、促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素、孕酮、睾酮、皮质醇和促甲状腺激素（TSH）检测结果异常。肌酐水平没有变化。FSH在两性中的强度均显示出剧烈变化（女性：769，P<0.0001）。虽然女性的TSH有许多异常，但分析显示P值无显著性差异（P=0.4558）。此外，男性的催乳素和睾酮平均水平以及女性的雌二醇平均水平均显示P值无显著性差异（分别为P=0.2077、P=0.1446、P=0.1351）。
结果表明，COVID-19直接或间接影响腺体及相关激素。
