Department of Rheumatology and Immunology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Medical School of Chinese PLA, Beijing, China.
Clin Interv Aging. 2024 May 15;19:827-841. doi: 10.2147/CIA.S455736. eCollection 2024.
This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese exercise, intestinal microecology, and rehabilitation therapies for individuals with limited limb movement. By analyzing multiple studies, the article aims to summarize the available evidence to manage sarcopenia in individuals with chronic diseases. The results strongly emphasize the role of resistance training in addressing chronic diseases and secondary sarcopenia. Maintaining the appropriate frequency and intensity of resistance training can help prevent muscle atrophy and effectively reduce inflammation. Although aerobic exercise has limited ability to improve skeletal muscle mass, it does have some positive effects on physical function. Building upon this, the article explores the potential benefits of combined training approaches, highlighting their helpfulness for overall quality of life. Additionally, the article also highlights the importance of dietary supplements in combating muscle atrophy in chronic diseases. It focuses on the importance of protein intake, supplements rich in essential amino acids and omega-3, as well as sufficient vitamin D to prevent muscle atrophy. Combining exercise with dietary supplements appears to be an effective strategy for preventing sarcopenia, although the optimal dosage and type of supplement remain unclear. Furthermore, the article explores the potential benefits of intestinal microecology in sarcopenia. Probiotics, prebiotics, and bacterial products are suggested as new treatment options for sarcopenia. Additionally, emerging therapies such as whole body vibration training, blood flow restriction, and electrical stimulation show promise in treating sarcopenia with limited limb movement. Overall, this article provides valuable insights into non-pharmacological strategies for managing sarcopenia in individuals with chronic diseases. It emphasizes the importance of a holistic and integrated approach that incorporates exercise, nutrition, and multidisciplinary interventions, which have the potential to promote health in the elderly population. Future research should prioritize high-quality randomized controlled trials and utilize wearable devices, smartphone applications, and other advanced surveillance methods to investigate the most effective intervention strategies for sarcopenia associated with different chronic diseases.
本文聚焦于一系列非药物策略,以管理慢性病中的肌肉减少症,包括运动、膳食补充剂、传统中医运动、肠道微生态以及针对肢体活动受限个体的康复治疗。通过对多项研究进行分析,本文旨在总结现有证据,以管理慢性病患者的肌肉减少症。研究结果强烈强调了抗阻训练在应对慢性病和继发性肌肉减少症中的作用。保持适当的抗阻训练频率和强度有助于预防肌肉萎缩并有效减轻炎症。虽然有氧运动改善骨骼肌质量的能力有限,但它确实对身体功能有一些积极影响。在此基础上,本文探讨了联合训练方法的潜在益处,强调了其对整体生活质量的帮助。此外,本文还强调了膳食补充剂在对抗慢性病中肌肉萎缩的重要性。重点关注蛋白质摄入、富含必需氨基酸和欧米伽 3 的补充剂以及足够的维生素 D 以预防肌肉萎缩。运动与膳食补充相结合似乎是预防肌肉减少症的有效策略,但最佳剂量和补充剂类型仍不清楚。此外,本文还探讨了肠道微生态在肌肉减少症中的潜在益处。益生菌、益生元以及细菌产物被认为是肌肉减少症的新治疗选择。此外,全身振动训练、血流限制和电刺激等新兴疗法在治疗肢体活动受限的肌肉减少症方面显示出潜力。总体而言,本文为管理慢性病患者肌肉减少症的非药物策略提供了有价值的见解。它强调了采取整体和综合方法的重要性,该方法将运动、营养和多学科干预措施结合起来,有潜力促进老年人群的健康。未来的研究应优先进行高质量的随机对照试验,并利用可穿戴设备、智能手机应用程序和其他先进的监测方法,研究针对不同慢性病相关肌肉减少症的最有效干预策略。