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The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review.营养在老年患者肌少症治疗中的作用:从线粒体活性恢复到肌肉性能改善的系统评价。
Nutrients. 2023 Aug 24;15(17):3703. doi: 10.3390/nu15173703.
2
Feasibility and safety of exercise during chemotherapy in people with gastrointestinal cancers: a pilot study.运动在胃肠道癌症化疗期间的可行性和安全性:一项初步研究。
Support Care Cancer. 2023 Sep 5;31(10):561. doi: 10.1007/s00520-023-08017-6.
3
Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline.普雷沃氏菌属 CP 可通过减轻肌肉质量损失和功能下降来缓解肌肉减少症。
J Cachexia Sarcopenia Muscle. 2023 Oct;14(5):2275-2288. doi: 10.1002/jcsm.13313. Epub 2023 Aug 17.
4
Nutritional Strategies to Prevent Muscle Loss and Sarcopenia in Chronic Kidney Disease: What Do We Currently Know?营养策略预防慢性肾脏病的肌肉减少症和肌少症:我们目前知道什么?
Nutrients. 2023 Jul 11;15(14):3107. doi: 10.3390/nu15143107.
5
Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial.力量训练比有氧运动更能有效改善体重正常 2 型糖尿病患者的血糖控制和身体成分:一项随机对照试验。
Diabetologia. 2023 Oct;66(10):1897-1907. doi: 10.1007/s00125-023-05958-9. Epub 2023 Jul 26.
6
Advances in nutritional supplementation for sarcopenia management.用于肌肉减少症管理的营养补充剂的进展。
Front Nutr. 2023 Jul 10;10:1189522. doi: 10.3389/fnut.2023.1189522. eCollection 2023.
7
Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective.肠道微生物群与炎症性疾病的双向关系对饮食的影响:特别强调肠易激综合征:现状和未来展望。
Nutrients. 2023 Jun 29;15(13):2956. doi: 10.3390/nu15132956.
8
Standard Hypercaloric, Hyperproteic vs. Leucine-Enriched Oral Supplements in Patients with Cancer-Induced Sarcopenia, a Randomized Clinical Trial.癌症相关性肌肉减少症患者的标准高卡路里、高蛋白与亮氨酸富集型口服补充剂:一项随机临床试验。
Nutrients. 2023 Jun 12;15(12):2726. doi: 10.3390/nu15122726.
9
Current and investigational medications for the treatment of sarcopenia.目前和正在研究用于治疗肌肉减少症的药物。
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10
Exploring the impact of exercise and essential amino acid plus cholecalciferol supplementation on physical fitness and body composition in multiple sclerosis: A case study.探索运动以及补充必需氨基酸加胆钙化醇对多发性硬化症患者体能和身体成分的影响:一项案例研究。
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非药物策略在慢性病肌少症管理中的应用。

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases.

机构信息

Department of Rheumatology and Immunology, First Medical Center of Chinese PLA General Hospital, Beijing, China.

Medical School of Chinese PLA, Beijing, China.

出版信息

Clin Interv Aging. 2024 May 15;19:827-841. doi: 10.2147/CIA.S455736. eCollection 2024.

DOI:10.2147/CIA.S455736
PMID:38765795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11102744/
Abstract

This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese exercise, intestinal microecology, and rehabilitation therapies for individuals with limited limb movement. By analyzing multiple studies, the article aims to summarize the available evidence to manage sarcopenia in individuals with chronic diseases. The results strongly emphasize the role of resistance training in addressing chronic diseases and secondary sarcopenia. Maintaining the appropriate frequency and intensity of resistance training can help prevent muscle atrophy and effectively reduce inflammation. Although aerobic exercise has limited ability to improve skeletal muscle mass, it does have some positive effects on physical function. Building upon this, the article explores the potential benefits of combined training approaches, highlighting their helpfulness for overall quality of life. Additionally, the article also highlights the importance of dietary supplements in combating muscle atrophy in chronic diseases. It focuses on the importance of protein intake, supplements rich in essential amino acids and omega-3, as well as sufficient vitamin D to prevent muscle atrophy. Combining exercise with dietary supplements appears to be an effective strategy for preventing sarcopenia, although the optimal dosage and type of supplement remain unclear. Furthermore, the article explores the potential benefits of intestinal microecology in sarcopenia. Probiotics, prebiotics, and bacterial products are suggested as new treatment options for sarcopenia. Additionally, emerging therapies such as whole body vibration training, blood flow restriction, and electrical stimulation show promise in treating sarcopenia with limited limb movement. Overall, this article provides valuable insights into non-pharmacological strategies for managing sarcopenia in individuals with chronic diseases. It emphasizes the importance of a holistic and integrated approach that incorporates exercise, nutrition, and multidisciplinary interventions, which have the potential to promote health in the elderly population. Future research should prioritize high-quality randomized controlled trials and utilize wearable devices, smartphone applications, and other advanced surveillance methods to investigate the most effective intervention strategies for sarcopenia associated with different chronic diseases.

摘要

本文聚焦于一系列非药物策略,以管理慢性病中的肌肉减少症,包括运动、膳食补充剂、传统中医运动、肠道微生态以及针对肢体活动受限个体的康复治疗。通过对多项研究进行分析,本文旨在总结现有证据,以管理慢性病患者的肌肉减少症。研究结果强烈强调了抗阻训练在应对慢性病和继发性肌肉减少症中的作用。保持适当的抗阻训练频率和强度有助于预防肌肉萎缩并有效减轻炎症。虽然有氧运动改善骨骼肌质量的能力有限,但它确实对身体功能有一些积极影响。在此基础上,本文探讨了联合训练方法的潜在益处,强调了其对整体生活质量的帮助。此外,本文还强调了膳食补充剂在对抗慢性病中肌肉萎缩的重要性。重点关注蛋白质摄入、富含必需氨基酸和欧米伽 3 的补充剂以及足够的维生素 D 以预防肌肉萎缩。运动与膳食补充相结合似乎是预防肌肉减少症的有效策略,但最佳剂量和补充剂类型仍不清楚。此外,本文还探讨了肠道微生态在肌肉减少症中的潜在益处。益生菌、益生元以及细菌产物被认为是肌肉减少症的新治疗选择。此外,全身振动训练、血流限制和电刺激等新兴疗法在治疗肢体活动受限的肌肉减少症方面显示出潜力。总体而言,本文为管理慢性病患者肌肉减少症的非药物策略提供了有价值的见解。它强调了采取整体和综合方法的重要性,该方法将运动、营养和多学科干预措施结合起来,有潜力促进老年人群的健康。未来的研究应优先进行高质量的随机对照试验,并利用可穿戴设备、智能手机应用程序和其他先进的监测方法,研究针对不同慢性病相关肌肉减少症的最有效干预策略。