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播散性单纯疱疹病毒1型感染在一名骨肉瘤化疗后中性粒细胞减少的患者中表现为广泛口腔溃疡、肺炎和回肠结肠炎。

Disseminated herpes simplex virus type 1 infection manifested as extensive oral ulcers, pneumonitis, and ileo-colitis in a neutropenic patient post-chemotherapy for osteosarcoma.

作者信息

Patamatamkul Samadhi, Sukswai Narittee, Mangkalamanee Onjira, Plongla Rongpong

机构信息

Department of Medicine, Faculty of Medicine, Suddhavej Hospital, Mahasarakham University, Maha Sarakham, Thailand.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial, Thai Red Cross Society, Bangkok, Thailand.

出版信息

IDCases. 2024 May 3;36:e01978. doi: 10.1016/j.idcr.2024.e01978. eCollection 2024.

DOI:10.1016/j.idcr.2024.e01978
PMID:38765798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11101683/
Abstract

Herpes simplex virus (HSV) is a common cause of recurrent oropharyngeal ulcers or stomatitis resulting from the reactivation of latent infection since childhood. Extensive ulceration and dissemination to vital organs such as pneumonitis or colitis is mostly encountered among hematologic malignancy or hematologic stem cell transplants. We hereby reported a case with osteosarcoma who developed disseminated HSV infection during neutropenia after chemotherapy.

摘要

单纯疱疹病毒（HSV）是复发性口咽溃疡或口腔炎的常见病因，源于儿童期潜伏感染的重新激活。广泛溃疡并扩散至重要器官，如肺炎或结肠炎，多见于血液系统恶性肿瘤或造血干细胞移植患者。我们在此报告一例骨肉瘤患者，在化疗后中性粒细胞减少期间发生播散性HSV感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/66d6e93086fc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/dcfb83a2bb57/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/f9b059e74b7c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/66d6e93086fc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/dcfb83a2bb57/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/f9b059e74b7c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e07/11101683/66d6e93086fc/gr3.jpg

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Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus.实体瘤和血液系统恶性肿瘤患者疱疹病毒再激活的管理：德国血液学和肿瘤医学学会传染病工作组（AGIHO）关于单纯疱疹病毒 1 型、单纯疱疹病毒 2 型和水痘带状疱疹病毒指南的更新。
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Prevention and Treatment of Cancer-Related Infections, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.《癌症相关感染的预防和治疗》，第 2.2016 版，NCCN 肿瘤学临床实践指南。
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