Zhao Xuan, Pang Jiaman, Zhang Wanghong, Peng Xie, Yang Zhenguo, Bai Guangdong, Xia Yaoyao
College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Yunnan Vocational College of Agriculture, Kunming 650211, China.
Anim Nutr. 2024 Mar 26;17:123-133. doi: 10.1016/j.aninu.2024.03.005. eCollection 2024 Jun.
The intestinal architecture of piglets is vulnerable to disruption during weaning transition and leads to diarrhea, frequently accompanied by inflammation and metabolic disturbances (including amino acid metabolism). Tryptophan (Trp) plays an essential role in orchestrating intestinal immune tolerance through its metabolism via the kynurenine, 5-hydroxytryptamine, or indole pathways, which could be dictated by the gut microbiota either directly or indirectly. Emerging evidence suggests a strong association between piglet diarrhea and Trp metabolism. Here we aim to summarize the intricate balance of microbiota-host crosstalk by analyzing alterations in both the host and microbial pathways of Trp and discuss how Trp metabolism may affect piglet diarrhea. Overall, this review could provide valuable insights to explore effective strategies for managing piglet diarrhea and the related challenges.
仔猪的肠道结构在断奶过渡期间容易受到破坏，并导致腹泻，常伴有炎症和代谢紊乱（包括氨基酸代谢）。色氨酸（Trp）通过犬尿氨酸、5-羟色胺或吲哚途径进行代谢，在协调肠道免疫耐受方面发挥着重要作用，而肠道微生物群可直接或间接决定这些途径。新出现的证据表明仔猪腹泻与色氨酸代谢之间存在密切关联。在这里，我们旨在通过分析色氨酸在宿主和微生物途径中的变化，总结微生物群与宿主相互作用的复杂平衡，并讨论色氨酸代谢如何影响仔猪腹泻。总体而言，本综述可为探索管理仔猪腹泻及相关挑战的有效策略提供有价值的见解。
