Department of Pediatrics, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Department of Ophthalmology, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Indian J Ophthalmol. 2024 Nov 1;72(11):1618-1623. doi: 10.4103/IJO.IJO_2594_23. Epub 2024 May 20.
To evaluate the ocular surface (OS) parameters in the pediatric migraine patients (PMPs).
This prospective case-control study consisted of 51 PMPs (PMP group) and 55 healthy pediatric patients (HPP group). In all participants, tear function was evaluated subjectively using the Ocular Surface Disease Index (OSDI) questionnaire, objectively using Schirmer tear test (STT) and tear film disintegration time (TBUT), and with clinical and laboratory examinations (conjunctival impression cytology). The PMP group was subdivided into two groups according to their aura.
The mean age and gender distribution of the study groups were almost the same ( P > 0.05 for both of them). In the PMP group, both the STT value and the TBUT value were significantly lower than those determined in the HPP group ( P = 0.021 and P = 0.018, respectively). In the PMP group, the OSDI scores were higher than those in the HPP group ( P = 0.032). In the PMP group, the goblet cell density values were lower than those in the HPP group ( P = 0.01). With regard to the aura, the TBUT and STT values were nonsignificantly lower in the PMP aura-positive group than in the PMP aura-negative group ( P > 0.05 for both of them). The OSDI assessment was similar in both the groups. With regard to the goblet cell count, it was observed to be less in the PMP aura-positive group than in the PMP aura-negative group ( P = 0.01).
Influence of OS in children with migraine was also demonstrated using the samples taken from the conjunctiva. These changes were also demonstrated by objective tests such as STT and TBUT. Both clinical objective evaluations and pathologic changes were more prominent in the migraine with aura group.
评估小儿偏头痛患者（PMP）的眼表（OS）参数。
本前瞻性病例对照研究纳入 51 例 PMP（PMP 组）和 55 例健康儿科患者（HPP 组）。在所有参与者中，使用眼表疾病指数（OSDI）问卷对泪液功能进行主观评估，使用泪液分泌试验（STT）和泪膜破裂时间（TBUT）进行客观评估，并进行临床和实验室检查（结膜印迹细胞学）。根据有无先兆，将 PMP 组分为两组。
研究组的平均年龄和性别分布几乎相同（两者的 P 值均>0.05）。在 PMP 组中，STT 值和 TBUT 值均明显低于 HPP 组（P=0.021 和 P=0.018）。在 PMP 组中，OSDI 评分高于 HPP 组（P=0.032）。在 PMP 组中，杯状细胞密度值低于 HPP 组（P=0.01）。就先兆而言，PMP 伴先兆阳性组的 TBUT 和 STT 值较 PMP 伴先兆阴性组无显著降低（两者的 P 值均>0.05）。两组的 OSDI 评估相似。就杯状细胞计数而言，PMP 伴先兆阳性组较 PMP 伴先兆阴性组明显减少（P=0.01）。
通过结膜样本也证明了偏头痛患儿 OS 的影响。这些变化也通过 STT 和 TBUT 等客观检查来证明。偏头痛伴先兆组的临床客观评估和病理变化更为明显。
