Trautmannsberger Ilona, Plagg Barbara, Adamek Ina, Mader Silke, de Luca Daniele, Esposito Susanna, Silfverdal Sven Arne, Zimmermann Luc J I, Tischer Christina
European Foundation for the Care of Newborn Infants (EFCNI), Hofmannstraße 7a, 81379, Munich, Germany.
Department of Paediatrics, Research School for Oncology and Reproduction, Maastricht UMC+, 6229 ER, Maastricht, The Netherlands.
Infect Dis Ther. 2024 Jul;13(7):1531-1573. doi: 10.1007/s40121-024-00989-0. Epub 2024 May 20.
Since the majority of hospitalisations due to RSV occur in young children, the illness profoundly influences the entire family. However, comprehensive evidence regarding its overall effects remains limited. The ResQ Family study aims to investigate the burden of RSV-induced pediatric hospitalisation on affected families.
Spanning the 2022-2023 RSV season, an interdisciplinary, observational study was conducted in Germany, France, Italy and Sweden. Using an online questionnaire, parents and caregivers of children (< 24 months of age) with an RSV-induced hospitalisation were recruited. Information was gathered on topics related to RSV and parental health-related quality of life (HRQoL) during the acute infection phase (t0) and 6 weeks later (t1). Descriptive evaluations of the data set were performed during t0 and regarding a potential change over the observation period (t0 vs. t1). Subgroup analysis aimed to further identify differences across the countries.
A total set of 138 affected parents/caregivers were included in the study, with 59 participants responding to the follow-up survey (t1). Particularly during the acute infection phase, parental HRQoL was shown to be negatively influenced by the child's RSV infection [total score (p < 0.001, d = 0.54), parent HRQoL summary score (p < 0.001, d = 0.67) and family functioning summary score (p = 0.007, d = 0.33)]. Significant disparities in disease awareness and support structures were observed across Europe, with France and Sweden showing notably higher levels.
The ResQ Family study provides convincing evidence that RSV-associated hospitalisations in young children across Europe generate a multifaced burden for the entire family, partly even beyond the acute infection phase. Standardised approaches for disease prevention at societal, educational and policy levels are needed to guarantee every newborn the best possible start into life.
ClinicalTrials.gov, identifier, NCT05550545.
由于大多数因呼吸道合胞病毒（RSV）导致的住院病例发生在幼儿身上，这种疾病对整个家庭产生了深远影响。然而，关于其总体影响的全面证据仍然有限。ResQ家庭研究旨在调查RSV引起的儿科住院对受影响家庭的负担。
在2022 - 2023年RSV流行季节期间，在德国、法国、意大利和瑞典进行了一项跨学科的观察性研究。通过在线问卷，招募了因RSV导致住院的24个月以下儿童的父母和照料者。收集了急性感染期（t0）和6周后（t1）与RSV以及父母健康相关生活质量（HRQoL）相关主题的信息。在t0期间以及关于观察期内的潜在变化（t0与t1）对数据集进行了描述性评估。亚组分析旨在进一步确定各国之间的差异。
该研究共纳入了138名受影响的父母/照料者，其中59名参与者回复了随访调查（t1）。特别是在急性感染期，儿童的RSV感染对父母的HRQoL产生了负面影响[总分（p < 0.001，d = 0.54），父母HRQoL汇总评分（p < 0.001，d = 0.67）和家庭功能汇总评分（p = 0.007，d = 0.33）]。在欧洲各地观察到疾病认知和支持结构存在显著差异，法国和瑞典的水平明显更高。
ResQ家庭研究提供了令人信服的证据，表明欧洲各地幼儿因RSV相关住院给整个家庭带来了多方面的负担，部分负担甚至超出急性感染期。需要在社会、教育和政策层面采取标准化的疾病预防方法，以确保每个新生儿都能有尽可能好的人生开端。
ClinicalTrials.gov，标识符，NCT05550545。
