The Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts, USA.
Sanofi, Swiftwater, Pennsylvania, USA.
J Infect Dis. 2022 Aug 15;226(Suppl 2):S236-S245. doi: 10.1093/infdis/jiac183.
Respiratory syncytial virus (RSV), a leading cause of lower respiratory tract infection in US children, reduces quality of life (QOL) of children, their caregivers, and families.
We conducted a systematic literature review in PubMed, EconLit, and other databases in the United States of articles published since 2000, derived utility lost per RSV episode from cohort studies, and performed a systematic analysis.
From 2262 unique citations, 35 received full-text review and 7 met the inclusion criteria (2 cohort studies, 4 modeling studies, and 1 synthesis). Pooled data from the 2 cohort studies (both containing only hospitalized premature infants) gave quality-adjusted life-year (QALY) losses per episode of 0.0173 at day 38. From the cohort study that also assessed caregivers' QOL, we calculated net QALYs lost directly attributable to RSV per nonfatal episode from onset to 60 days after onset for the child, caregiver, child-and-caregiver dyad of 0.0169 (167% over prematurity alone), 0.0031, and 0.0200, respectively.
Published data on QOL of children in the United States with RSV are scarce and consider only premature hospitalized infants, whereas most RSV episodes occur in children who were born at term and were otherwise healthy. QOL studies are needed beyond hospitalized premature infants.
呼吸道合胞病毒（RSV）是美国儿童下呼吸道感染的主要原因，降低了儿童、其照顾者和家庭的生活质量（QOL）。
我们在美国的 PubMed、EconLit 和其他数据库中进行了系统的文献综述，从队列研究中得出了每个 RSV 发作的效用损失，并进行了系统分析。
从 2262 条独特的引用中，有 35 条进行了全文审查，有 7 条符合纳入标准（2 项队列研究、4 项建模研究和 1 项综合研究）。来自 2 项队列研究（均仅包含住院早产儿）的合并数据给出了每例发作的质量调整生命年（QALY）损失为 0.0173 在第 38 天。从还评估了照顾者 QOL 的队列研究中，我们计算了每个非致命发作从发病到发病后 60 天直接归因于 RSV 的儿童、照顾者、儿童和照顾者二元组的净 QALY 损失分别为 0.0169（比单纯早产高 167%）、0.0031 和 0.0200。
美国关于 RSV 儿童 QOL 的已发表数据稀缺，仅考虑住院早产儿，而大多数 RSV 发作发生在足月出生且健康状况良好的儿童中。需要对住院早产儿以外的儿童进行 QOL 研究。
