School of Public Health, Wuhan University, Wuhan 430071, China.
School of Public Health, Wuhan University, Wuhan 430071, China; School of Nursing, Wuhan University, Wuhan 430071, China; Center for Chronic Disease Rehabilitation, School of Nursing, Wuhan University, Wuhan, China.
J Affect Disord. 2024 Aug 15;359:226-233. doi: 10.1016/j.jad.2024.05.069. Epub 2024 May 18.
The increasing incidence of depressive symptoms in diabetic patients contributes to the global burden of disease, but few epidemiological studies have evaluated the relationship between dietary flavonoids intake and depressive symptoms in diabetic patients in American adults.
This study intended to evaluate the associations of dietary flavonoids intake and depressive symptoms in diabetic patients in American adults.
We conducted a cross-sectional analysis of 1993 adults aged ≥20 years old who participated in the 2007-2008, 2009-2010, and 2017-2018 National Health and Nutrition Examination Surveys (NHANES). Chi-square test and independent-sample t-test were used to compare subjects' characteristics. Logistic regression model was further used to analyze the relationship between dietary flavonoid intake and depressive symptoms in diabetic patients. Restricted cubic spline (RCS) analysis was used to investigate the non-linear relationship between dietary flavonoid intake and the prevalence of depressive symptoms in diabetic patients. The weighted quartile sum (WQS) regression was used to analyze the effect of 29 flavonoids monomers.
The results showed that the total flavonoid intake in the third quartile (OR, 0.635; 95 % CI,0.419-0.962; P, 0.032) was significantly associated with a reduced risk of depressive symptoms in diabetic patients compared with the lowest quartile. And there was a U-shaped association between dietary flavonoid intake and risk of depressive symptoms in diabetic patients. Top contributors of flavonoid monomers were eriodictyol, naringenin, and theaflavin-3'-gallate, accounting for a percentage of 30.83 %, 22.17 %, and 6.92 %, respectively.
Moderate (56.07-207.12 mg/day) dietary flavonoid intake was associated with a reduced risk of depressive symptoms in diabetic patients. The important flavonoid monomers were eriodictyol, naringenin, and theaflavin-3'-gallate.
糖尿病患者抑郁症状的发生率不断上升，导致全球疾病负担加重，但很少有流行病学研究评估美国成年人糖尿病患者饮食类黄酮摄入与抑郁症状之间的关系。
本研究旨在评估美国成年人糖尿病患者饮食类黄酮摄入与抑郁症状之间的关系。
我们对 1993 名年龄≥20 岁的成年人进行了横断面分析，这些成年人参加了 2007-2008 年、2009-2010 年和 2017-2018 年的国家健康和营养调查（NHANES）。卡方检验和独立样本 t 检验用于比较受试者的特征。进一步使用 logistic 回归模型分析饮食类黄酮摄入与糖尿病患者抑郁症状之间的关系。限制性立方样条（RCS）分析用于研究饮食类黄酮摄入与糖尿病患者抑郁症状发生率之间的非线性关系。加权四分位和（WQS）回归用于分析 29 种类黄酮单体的影响。
结果表明，与最低四分位数相比，第三四分位数（OR，0.635；95%CI，0.419-0.962；P，0.032）的总类黄酮摄入量与糖尿病患者抑郁症状风险降低显著相关。饮食类黄酮摄入与糖尿病患者抑郁症状风险之间存在 U 型关系。类黄酮单体的主要贡献者是桔皮素、柚皮苷和茶黄素-3'-没食子酸酯，分别占 30.83%、22.17%和 6.92%。
中等（56.07-207.12mg/天）饮食类黄酮摄入与糖尿病患者抑郁症状风险降低相关。重要的类黄酮单体是桔皮素、柚皮苷和茶黄素-3'-没食子酸酯。
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