Deng Ming-Gang, Liu Fang, Wang Kai, Zhang Min-Jie, Feng Qianqian, Liu Jiewei
Department of Psychiatry, Wuhan Mental Health Center, Wuhan 430012, Hubei, China; Department of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan 430012, Hubei, China.
School of Public Health, Wuhan University, Wuhan 430071, Hubei, China.
Gen Hosp Psychiatry. 2024 Jan-Feb;86:75-84. doi: 10.1016/j.genhosppsych.2023.12.005. Epub 2023 Dec 15.
To investigate the relationship between dietary flavonoid intake and depression symptoms in American adults.
Data sets were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2008, 2009-2010, and 2017-2018 survey cycles. Both males and females aged 18 years and older with complete information about dietary flavonoid intake (isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols), depression symptoms, and covariates were included. Logistic regression models were conducted to calculate the odds ratio (OR) of single dietary flavonoid subclass intake on depression, and the restricted cubic spline (RCS) models were utilized to explore the corresponding dose-response relationships. Additionally, we implemented the weighted quantile sum (WQS) regression and quantile g-computation (qgcomp) models to estimate the mixed effects of six flavonoid subclasses and identify the predominant types.
After multivariable adjustments, people with higher consumption of flavanones (OR: 0.68, 95% CI: 0.52-0.90, p = 0.008), flavones (OR: 0.63, 95% CI: 0.46-0.87, p = 0.007), flavonols (OR: 0.66, 95% CI: 0.49-0.89, p = 0.008), and total flavonoids (OR: 0.69, 95% CI: 0.50-0.95, p = 0.024) had lower odds of depression symptoms. Meanwhile, significant dose-response relationships were supported by the RCS models. However, no obvious associations between isoflavones, anthocyanidins, flavan-3-ols, and the odds of suffering from depression symptoms were found by the logistic regression models and RCS models. As for the mixed effect, the WQS and qgcomp models both demonstrated that the mixture of six flavonoid subclasses was inversely related to the odds ratios of depression symptoms, and flavones, flavanones, and anthocyanidins were the top 3 contributors.
Our study implied dietary flavonoid intake was associated with the decreased probability of depression symptoms in U.S. adults, among which flavones, flavanones, and anthocyanidins may occupy the predominant roles.
研究美国成年人饮食中黄酮类化合物摄入量与抑郁症状之间的关系。
数据集来自2007 - 2008年、2009 - 2010年和2017 - 2018年的美国国家健康与营养检查调查（NHANES）周期。纳入年龄在18岁及以上、具有饮食中黄酮类化合物摄入量（异黄酮、花青素、黄烷-3-醇、黄烷酮、黄酮和黄酮醇）、抑郁症状及协变量完整信息的男性和女性。采用逻辑回归模型计算单一饮食黄酮类亚类摄入量与抑郁的比值比（OR），并利用受限立方样条（RCS）模型探索相应的剂量反应关系。此外，我们实施了加权分位数和（WQS）回归和分位数g计算（qgcomp）模型，以估计六种黄酮类亚类的混合效应并确定主要类型。
经过多变量调整后，黄烷酮摄入量较高者（OR：0.68，95%CI：0.52 - 0.90，p = 0.008）、黄酮摄入量较高者（OR：0.63，95%CI：0.46 - 0.87，p = 0.007）、黄酮醇摄入量较高者（OR：0.66，95%CI：0.49 - 0.89，p = 0.008）和总黄酮摄入量较高者（OR：0.69，95%CI：0.50 - 0.95，p = 0.024）出现抑郁症状的几率较低。同时，RCS模型支持显著的剂量反应关系。然而，逻辑回归模型和RCS模型未发现异黄酮、花青素、黄烷-3-醇与抑郁症状发生几率之间存在明显关联。至于混合效应，WQS和qgcomp模型均表明六种黄酮类亚类的混合物与抑郁症状的比值比呈负相关，且黄酮、黄烷酮和花青素是前三大贡献因素。
我们的研究表明，美国成年人饮食中黄酮类化合物的摄入量与抑郁症状发生概率的降低有关，其中黄酮、黄烷酮和花青素可能起主要作用。
