Department of Psychosomatic Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China; National Clinical Research Center for Chinese Medicine Acupuncture and Mox-ibustion, Tianjin 300381, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
J Affect Disord. 2024 Jan 15;345:293-299. doi: 10.1016/j.jad.2023.10.128. Epub 2023 Oct 27.
Depressive symptoms is an important public health problem. The aim of the present study is to examine the association of dietary flavonoid intake with risk of depressive symptoms.
In this study, we conducted an assessment to investigate the potential association between dietary flavonoid intake and the risk of depressive symptoms. Our analysis was based on a nationally representative sample of 9674 adults who participated in the 2007-2010 and 2017-2018 National Health and Nutrition Examination Surveys. Flavonoid intake was measured using a 24-hour dietary recall method, while depressive symptoms was evaluated using the Patient Health Questionnaire-9. To examine the relationship between dietary flavonoid intake and the risk of depressive symptoms, we employed logistic regression, subgroup and restricted cubic spline models.
Following multivariate adjustment, the study found a negative association between total flavonoids, anthocyanidins, flavanones, flavones, isoflavones and the risk of depressive symptoms. In subgroup analysis, total flavonoid intake was inversely associated with risk of depressive symptoms among women whereas no association was found among man. Additionally, a non-linear relationship was observed between total flavonoid intake and depressive symptoms, with statistical significance (P for nonlinearity <0.001).
The present study employed a cross-sectional design, which precludes the establishment of causality. Furthermore, the data relied on self-reported measures.
In present study, moderate total flavonoids intake, but not high intake, was associated with lower odds of depressive symptoms suggesting a U-shaped association.
抑郁症状是一个重要的公共卫生问题。本研究旨在探讨饮食类黄酮摄入与抑郁症状风险之间的关联。
本研究通过评估来调查饮食类黄酮摄入与抑郁症状风险之间的潜在关联。我们的分析基于参加了 2007-2010 年和 2017-2018 年全国健康与营养调查的 9674 名成年人的全国代表性样本。采用 24 小时膳食回忆法测量类黄酮的摄入量，而抑郁症状则采用患者健康问卷-9 进行评估。为了研究饮食类黄酮摄入与抑郁症状风险之间的关系，我们采用了逻辑回归、亚组和限制立方样条模型。
在进行多变量调整后，研究发现总类黄酮、花青素、黄烷酮、黄酮类、异黄酮与抑郁症状风险之间呈负相关。在亚组分析中，总类黄酮摄入量与女性抑郁症状风险呈负相关，而男性则无相关性。此外，总类黄酮摄入量与抑郁症状之间存在非线性关系，具有统计学意义（非线性检验 P<0.001）。
本研究采用了横断面设计，因此无法确立因果关系。此外，数据依赖于自我报告的测量。
在本研究中，中等水平的总类黄酮摄入，而不是高水平的摄入，与较低的抑郁症状风险相关，表明存在 U 型关联。
