School of Public Health, Wuhan University, Wuhan 430071, China.
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030, Wuhan, China.
Food Funct. 2023 May 11;14(9):4183-4190. doi: 10.1039/d3fo00242j.
Few epidemiological studies have investigated the relationship between flavonoids and diabetic nephropathy (DN). Therefore, we explored the association between dietary flavonoid intake and DN among 1949 US adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2008, 2009-2010, and 2017-2018. Weighted logistic regression models demonstrated that the total flavonoid intake in the second (OR: 0.642; 95% CI: 0.456-0.906), third (OR: 0.665; 95% CI: 0.447-0.988), and the highest (OR: 0.551; 95% CI: 0.382-0.796) quantiles ( the lowest) were associated with the decreased risk of DN. Restricted cubic spline (RCS) analyses showed that the total flavonoid intake had a negative linear association with DN (-value for non-linearity was 0.003). Weighted quantile sum (WQS) regression analyses revealed that flavan-3-ols, flavones, and anthocyanidins were the main contributors for the combined effects of six flavonoid subclasses. Our findings suggested that higher dietary flavonoid intake was associated with a decreased risk of DN, with the greatest influence coming from flavan-3-ols, flavones, and anthocyanidins.
很少有流行病学研究调查黄酮类化合物与糖尿病肾病 (DN) 之间的关系。因此，我们在 2007-2008 年、2009-2010 年和 2017-2018 年的国家健康和营养检查调查 (NHANES) 中调查了 1949 名美国成年人的饮食黄酮类化合物摄入量与 DN 之间的关系。加权逻辑回归模型表明，第二（OR：0.642；95%CI：0.456-0.906）、第三（OR：0.665；95%CI：0.447-0.988）和最高（OR：0.551；95%CI：0.382-0.796）分位数（最低分位）的总黄酮类化合物摄入量与 DN 风险降低相关。限制立方样条（RCS）分析显示，总黄酮类化合物摄入量与 DN 呈负线性关系（非线性-值为 0.003）。加权分位数总和（WQS）回归分析表明，黄烷-3-醇、黄酮类化合物和花青素是六种黄酮类化合物亚类综合效应的主要贡献者。我们的研究结果表明，较高的饮食黄酮类化合物摄入量与 DN 风险降低相关，其中黄烷-3-醇、黄酮类化合物和花青素的影响最大。
