The Zigong Affiliated Hospital of Southwest Medical University, Zigong Mental Health Center, Zigong, China.
Psychogeriatrics. 2024 Jul;24(4):861-867. doi: 10.1111/psyg.13133. Epub 2024 May 20.
It is reported that reduced physical activity and malnutrition may trigger pneumonia, and the utilisation of the geriatric nutritional risk index (GNRI) upon admission to long-term nursing care can enable the implementation of accurate and timely rehabilitation and nutritional support, which may, in turn, minimise pneumonia incidence. However, to date, there is no reported association between GNRI and pneumonia among stable schizophrenic patients.
This is a retrospective investigation. We enrolled 434 hospitalised subjects aged ≥50 years, who were diagnosed with stable schizophrenia between January 2017 and June 2022. Baseline nutritional status information during the stable stage of schizophrenia was evaluated using body mass index, serum albumin, and GNRI. In addition, pneumonia-based information, including diagnosis and treatment, was retrospectively obtained within 1 year. To examine the potential association between nutrition indicators and pneumonia risk among stable schizophrenia patients, we employed a logistic regression analysis.
The pneumonia incidence among all stable schizophrenia patients was 10.14%, and there were no statistically significant difference between sexes (male vs. female, 10.63% vs. 9.44%, P = 0.687). Based on the univariate analysis of nutrition indicators and pneumonia, female patients exhibited a strong correlation between serum albumin and pneumonia (P = 0.022). Furthermore, we adjusted for potential influencing factors of pneumonia infection, and confirmed that only serum albumin was linked to pneumonia risk in female stable schizophrenia patients (odds ratio = 0.854, 95% CI: 0.749-0.975, P = 0.02).
Based on our analysis, serum albumin was strongly correlated with pneumonia risk in female stable schizophrenia patients.
据报道，体力活动减少和营养不良可能会引发肺炎，而在入住长期护理机构时使用老年营养风险指数（GNRI）可以实现准确和及时的康复和营养支持，从而最大限度地降低肺炎的发病率。然而，迄今为止，尚未有报道称 GNRI 与稳定期精神分裂症患者的肺炎有关。
这是一项回顾性研究。我们纳入了 434 名年龄≥50 岁、被诊断为稳定期精神分裂症的住院患者，这些患者的诊断时间在 2017 年 1 月至 2022 年 6 月之间。使用体重指数、血清白蛋白和 GNRI 评估稳定期精神分裂症患者的基线营养状况信息。此外，还回顾性地获得了 1 年内基于肺炎的信息，包括诊断和治疗。为了研究稳定期精神分裂症患者的营养指标与肺炎风险之间的潜在关联，我们采用了 logistic 回归分析。
所有稳定期精神分裂症患者的肺炎发病率为 10.14%，且男女之间无统计学差异（男性与女性分别为 10.63%和 9.44%，P=0.687）。根据营养指标与肺炎的单因素分析，女性患者的血清白蛋白与肺炎呈强相关（P=0.022）。此外，我们调整了肺炎感染的潜在影响因素，证实只有血清白蛋白与女性稳定期精神分裂症患者的肺炎风险相关（比值比=0.854，95%置信区间：0.749-0.975，P=0.02）。
根据我们的分析，血清白蛋白与女性稳定期精神分裂症患者的肺炎风险密切相关。
