Bissette G, Reynolds G P, Kilts C D, Widerlöv E, Nemeroff C B
JAMA. 1985 Dec 6;254(21):3067-9.
The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the human central nervous system was measured by radioimmunoassay in postmortem tissue of control patients and in those with histologically confirmed senile dementia of the Alzheimer type (SDAT). In the controls, CRF-LI was found in high concentrations in the hypothalamus and frontal cortex (Brodmann's area 10), in moderate concentrations in amygdala, substantia innominata, temporal and parietal cortex (Brodmann's areas 38 and 7), and the caudate nucleus, and in low concentrations in posterior hippocampus and nucleus accumbens. A marked reduction in the concentration of CRF-LI was observed in the frontal and temporal cortex (approximately 50%) as well as in the caudate nucleus (approximately 70%) in the SDAT group. The present findings suggest that neurons containing corticotropin-releasing factor are pathologically altered in SDAT, in addition to the previously described cholinergic and somatostatinergic neuronal degeneration.
采用放射免疫分析法，测定了对照患者及经组织学确诊为阿尔茨海默型老年性痴呆（SDAT）患者死后脑组织中促肾上腺皮质激素释放因子样免疫反应性物质（CRF-LI）的浓度。在对照组中，下丘脑和额叶皮质（布罗德曼第10区）的CRF-LI浓度较高，杏仁核、无名质、颞叶和顶叶皮质（布罗德曼第38区和第7区）以及尾状核中的浓度中等，而后海马和伏隔核中的浓度较低。在SDAT组中，额叶和颞叶皮质（约50%）以及尾状核（约70%）的CRF-LI浓度显著降低。目前的研究结果表明，除了先前描述的胆碱能和生长抑素能神经元变性外，含促肾上腺皮质激素释放因子的神经元在SDAT中也发生了病理改变。
