The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland.
The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland; Inserm, UMR-S 839, 75005 Paris, France.
Neuron. 2024 Aug 21;112(16):2669-2685. doi: 10.1016/j.neuron.2024.04.026. Epub 2024 May 20.
Behavioral strategies for survival rely on the updates the brain continuously makes based on the surrounding environment. External stimuli-neutral, positive, and negative-relay core information to the brain, where a complex anatomical network rapidly organizes actions, including approach or escape, and regulates emotions. Human neuroimaging and physiology in nonhuman primates, rodents, and teleosts suggest a pivotal role of the lateral habenula in translating external information into survival behaviors. Here, we review the literature describing how discrete habenular modules-reflecting the molecular signatures, anatomical connectivity, and functional components-are recruited by environmental stimuli and cooperate to prompt specific behavioral outcomes. We argue that integration of these findings in the context of valence processing for reinforcing or discouraging behaviors is necessary, offering a compelling model to guide future work.
行为策略的生存依赖于大脑不断更新基于周围环境。外部刺激——中性的、积极的和消极的——将核心信息传递给大脑，大脑中一个复杂的解剖网络迅速组织行动，包括接近或逃避，并调节情绪。人类神经影像学和非人类灵长类动物、啮齿动物和硬骨鱼的生理学研究表明，外侧缰核在将外部信息转化为生存行为方面起着关键作用。在这里，我们回顾了描述离散缰核模块如何被环境刺激招募并合作以提示特定行为结果的文献。我们认为，在对强化或抑制行为的效价处理的背景下整合这些发现是必要的，这为指导未来的工作提供了一个有说服力的模型。
