芬太尼、甲磺酸右美托咪定-芬太尼或盐酸苯海拉明-芬太尼预处理对麻醉犬食管和直肠温度的影响。

Influence of fentanyl, medetomidine-fentanyl or acepromazine-fentanyl premedication on oesophageal and rectal temperature in dogs under anaesthesia.

机构信息

Department of Surgery and Orthopaedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic.

出版信息

Vet Anaesth Analg. 2024 Jul-Aug;51(4):357-361. doi: 10.1016/j.vaa.2024.04.003. Epub 2024 Apr 10.

DOI:10.1016/j.vaa.2024.04.003

PMID:38772852

Abstract

OBJECTIVE

To compare changes in oesophageal (T-Oeso) and rectal (T-Rec) temperature in dogs during general anaesthesia and premedicated with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl.

STUDY DESIGN

Prospective, randomized, blind clinical study.

ANIMALS

A total of 120 healthy dogs, aged 2-10 years and weighing 5-20 kg.

METHODS

Dogs were randomly allocated to one of three groups. Animals of F group were premedicated with fentanyl (0.01 mg kg), MF group with medetomidine (0.005 mg kg) and fentanyl (0.01 mg kg) and AF group with acepromazine (0.01 mg kg) and fentanyl (0.01 mg kg). Anaesthesia was induced with propofol and maintained with isoflurane in oxygen-air mixture. Fentanyl was administered continuously (0.01 mg kg hour). The T-Oeso, T-Rec and ambient temperatures were recorded after induction (T0) and subsequently at 10 minute intervals for 60 minutes (T10-T60). Data were analysed using anova or their non-parametric equivalents (p < 0.05).

RESULTS

Median T-Oeso was significantly higher in MF group between T0-T20 compared with other groups. Median T-Oeso significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T30), 37.1 °C (T40), 36.9 °C (T50) and 36.6 °C (T60), in MF group from 38.3 °C (T0) to 37.7 °C (T30), 37.5 °C (T40), 37.2 °C (T50) and 37.1 °C (T60) and in AF group from 37.7 °C (T0) to 37.3 °C (T40), 37.2 °C (T50) and 37.1 °C (T60). The T-Rec significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T40), 37.2 °C (T50) and 36.9 °C (T60), in MF group from 38.3 °C (T0) to 37.5 °C (T50) and 37.4 °C (T60) and in AF group from 38.2 °C (T0) to 37.6 °C (T40), 37.5 °C (T50) and 37.4 °C (T60).

CONCLUSIONS AND CLINICAL RELEVANCE

Premedication with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl in the doses used decreased the T-Oeso and T-Rec. The T-Oeso at the beginning of anaesthesia was higher after premedication with medetomidine-fentanyl. However, this difference was not clinically significant.

摘要

目的

比较芬太尼、甲磺酸右美托咪定-芬太尼或盐酸苯海拉明-芬太尼预处理的犬全身麻醉期间食管（T-Oeso）和直肠（T-Rec）温度的变化。

研究设计

前瞻性、随机、盲法临床研究。

动物

120 只健康犬，年龄 2-10 岁，体重 5-20kg。

方法

犬随机分为三组。F 组动物用芬太尼（0.01mg/kg）预处理，MF 组用甲磺酸右美托咪定（0.005mg/kg）和芬太尼（0.01mg/kg）预处理，AF 组用盐酸苯海拉明（0.01mg/kg）和芬太尼（0.01mg/kg）预处理。用异丙酚诱导麻醉，并用异氟烷在氧气-空气混合物中维持。持续输注芬太尼（0.01mg/kg·h）。诱导后（T0）及随后每隔 10 分钟记录 T-Oeso、T-Rec 和环境温度 60 分钟（T10-T60）。使用方差分析或其非参数等效方法（p<0.05）分析数据。

结果

MF 组在 T0-T20 期间 T-Oeso 中位数明显高于其他组。F 组 T-Oeso 从 38.0°C（T0）降至 37.4°C（T30）、37.1°C（T40）、36.9°C（T50）和 36.6°C（T60），MF 组从 38.3°C（T0）降至 37.7°C（T30）、37.5°C（T40）、37.2°C（T50）和 37.1°C（T60），AF 组从 37.7°C（T0）降至 37.3°C（T40）、37.2°C（T50）和 37.1°C（T60），差异有统计学意义。F 组 T-Rec 从 38.0°C（T0）降至 37.4°C（T40）、37.2°C（T50）和 36.9°C（T60），MF 组从 38.3°C（T0）降至 37.5°C（T50）和 37.4°C（T60），AF 组从 38.2°C（T0）降至 37.6°C（T40）、37.5°C（T50）和 37.4°C（T60），差异有统计学意义。