Patrick M R, Blair I J, Feneck R O, Sebel P S
Postgrad Med J. 1985;61 Suppl 3:23-7.
Twenty patients scheduled for elective coronary surgery received either propofol ('Diprivan') 1.5 mg/kg in emulsion or thiopentone 2 mg/kg for induction of anaesthesia. Vecuronium was used for neuromuscular blockade. Cardiovascular dynamics were recorded every minute until 6 min after intubation. Anaesthesia with propofol was accompanied by a reduction in arterial pressure, the decrease being severe in two patients. This was largely due to a decrease in systemic vascular resistance. Thiopentone anaesthesia resulted in a smaller decrease in arterial pressure, but a marked increase in arterial pressure followed endotracheal intubation. Although the absence of haemodynamic changes following intubation during propofol anaesthesia is advantageous to the ischaemic myocardium, this has to be balanced by the variable and sometimes severe reduction in arterial pressure that occurred on induction.
20例计划进行择期冠状动脉手术的患者，在麻醉诱导时分别接受了1.5mg/kg丙泊酚（“得普利麻”）乳剂或2mg/kg硫喷妥钠。维库溴铵用于神经肌肉阻滞。插管后每分钟记录心血管动力学指标，直至6分钟。丙泊酚麻醉时动脉压降低，2例患者降低严重。这主要是由于全身血管阻力降低。硫喷妥钠麻醉时动脉压降低幅度较小，但气管插管后动脉压显著升高。虽然丙泊酚麻醉期间插管后无血流动力学变化对缺血心肌有利，但这必须与诱导时动脉压的变化及有时严重降低相权衡。
