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食欲素神经元在活动小鼠中跟踪血糖的时间特征。

Orexin neurons track temporal features of blood glucose in behaving mice.

机构信息

Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.

Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

出版信息

Nat Neurosci. 2024 Jul;27(7):1299-1308. doi: 10.1038/s41593-024-01648-w. Epub 2024 May 21.

DOI:10.1038/s41593-024-01648-w
PMID:38773350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11239495/
Abstract

Does the brain track how fast our blood glucose is changing? Knowing such a rate of change would enable the prediction of an upcoming state and a timelier response to this new state. Hypothalamic arousal-orchestrating hypocretin/orexin neurons (HONs) have been proposed to be glucose sensors, yet whether they track glucose concentration (proportional tracking) or rate of change (derivative tracking) is unknown. Using simultaneous recordings of HONs and blood glucose in behaving male mice, we found that maximal HON responses occur in considerable temporal anticipation (minutes) of glucose peaks due to derivative tracking. Analysis of >900 individual HONs revealed glucose tracking in most HONs (98%), with derivative and proportional trackers working in parallel, and many (65%) HONs multiplexed glucose and locomotion information. Finally, we found that HON activity is important for glucose-evoked locomotor suppression. These findings reveal a temporal dimension of brain glucose sensing and link neurobiological and algorithmic views of blood glucose perception in the brain's arousal orchestrators.

摘要

大脑是否能追踪我们血糖变化的速度？了解这种变化率将能够预测即将到来的状态，并对这种新状态做出更及时的反应。下丘脑觉醒调节的食欲肽/下丘脑泌素神经元（HON）已被提议作为葡萄糖传感器，但它们是否追踪葡萄糖浓度（比例追踪）或变化率（导数追踪）尚不清楚。我们使用行为雄性小鼠中 HON 和血糖的同步记录发现，由于导数追踪，HON 的最大反应发生在葡萄糖峰值的相当大的时间预期（分钟）内。对>900 个单个 HON 的分析表明，大多数 HON（98%）都具有葡萄糖追踪功能，导数和比例追踪器并行工作，许多（65%）HON 混合了葡萄糖和运动信息。最后，我们发现 HON 活动对于葡萄糖引起的运动抑制很重要。这些发现揭示了大脑葡萄糖感应的时间维度，并将血糖感知的神经生物学和算法观点联系起来，这些观点存在于大脑的觉醒协调器中。

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