代谢综合征与结直肠癌风险关系的遗传预测：一项孟德尔随机化研究
Genetic prediction of the relationship between metabolic syndrome and colorectal cancer risk: a Mendelian randomization study.
作者信息
Yuan Chendong, Shu Xufeng, Hu Zhenzhen, Jie Zhigang
机构信息
Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Medical Innovation Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
出版信息
Diabetol Metab Syndr. 2024 May 22;16(1):109. doi: 10.1186/s13098-024-01351-7.
BACKGROUND
Despite a growing body of observational studies indicating a potential link between metabolic syndrome and colorectal cancer, a definitive causal relationship has yet to be established. This study aimed to elucidate the causal relationship between metabolic syndrome and colorectal cancer through Mendelian randomization.
METHODS
We screened for instrumental variables associated with metabolic syndrome and its diagnostic components and with colorectal cancer through the use of a genome-wide association study database, and conducted a preliminary Mendelian randomization analysis. To corroborate the dependability of our conclusions, an additional dataset was used for replication analysis in a Mendelian randomization method, which was further integrated with a meta-analysis.
RESULTS
Preliminary analysis using the inverse variance weighted method revealed positive correlations between metabolic syndrome (OR [95% CI] = 1.37[1.15-1.63], P = 5.02 × 10) and waist circumference (OR [95% CI] = 1.39[1.21-1.61], P = 7.38 × 10) and the risk of colorectal cancer. Replication analysis also revealed the same results: metabolic syndrome (OR [95% CI] = 1.24[1.02-1.51], P = 0.030) and waist circumference (OR [95% CI] = 1.23[1.05-1.45], P = 0.013). The meta-analysis results further confirmed the associations between metabolic syndrome (OR [95% CI] = 1.31[1.15-1.49], P < 0.001) and waist circumference (OR [95% CI] = 1.32[1.18-1.47], P < 0.001) and colorectal cancer.
CONCLUSION
Our study indicated that metabolic syndrome increases the risk of CRC, particularly in patients with abdominal obesity.
背景
尽管越来越多的观察性研究表明代谢综合征与结直肠癌之间存在潜在联系，但尚未确定明确的因果关系。本研究旨在通过孟德尔随机化阐明代谢综合征与结直肠癌之间的因果关系。
方法
我们通过使用全基因组关联研究数据库筛选与代谢综合征及其诊断成分以及与结直肠癌相关的工具变量，并进行了初步的孟德尔随机化分析。为了证实我们结论的可靠性，使用另一个数据集以孟德尔随机化方法进行重复分析，并进一步与荟萃分析相结合。
结果
使用逆方差加权法的初步分析显示，代谢综合征（比值比[95%置信区间]=1.37[1.15 - 1.63]，P = 5.02×10）和腰围（比值比[95%置信区间]=1.39[1.21 - 1.61]，P = 7.38×10）与结直肠癌风险之间存在正相关。重复分析也得出了相同的结果：代谢综合征（比值比[95%置信区间]=1.24[1.02 - 1.51]，P = 0.030）和腰围（比值比[95%置信区间]=1.23[1.05 - 1.45]，P = 0.013）。荟萃分析结果进一步证实了代谢综合征（比值比[95%置信区间]=1.31[1.15 - 1.49]，P < 0.001）和腰围（比值比[95%置信区间]=1.32[1.18 - 1.47]，P < 0.001）与结直肠癌之间的关联。
结论
我们的研究表明，代谢综合征会增加患结直肠癌的风险，尤其是腹部肥胖的患者。
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