Institute of Pathogenic Biology, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang Medical School, University of South China, Hengyang, Hunan, P.R. China.
Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, P.R. China.
Virulence. 2024 Dec;15(1):2351234. doi: 10.1080/21505594.2024.2351234. Epub 2024 May 21.
infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, requires a variety of nutrients and substrates from host cells, particularly sphingomyelin, cholesterol, iron, amino acids, and the mannose-6-phosphate receptor, which are essential for inclusion development. Here, we summarize the recent advances in nutrient acquisition mechanism by hijacking host cell vesicular transport, which plays an important role in chlamydial growth and development. obtains the components necessary to complete its intracellular developmental cycle by recruiting Rab proteins (major vesicular trafficking regulators) and Rab effector proteins to the inclusion, interfering with Rab-mediated multivesicular trafficking, reorienting the nutrition of host cells, and reconstructing the intracellular niche environment. Consequently, exploring the role of vesicular transport in nutrient acquisition offers a novel perspective on new approaches for preventing and treating infection.
感染是重要的公共卫生疾病病因，目前尚无有效的疫苗。由于其独特的细胞内生活方式，需要宿主细胞提供多种营养物质和底物，特别是神经鞘磷脂、胆固醇、铁、氨基酸和甘露糖-6-磷酸受体，这些都是包涵体发育所必需的。在这里，我们总结了近年来通过劫持宿主细胞囊泡运输来获取营养的机制的最新进展，这在衣原体的生长和发育中起着重要作用。通过将 Rab 蛋白（主要囊泡运输调节剂）和 Rab 效应蛋白募集到包涵体中，干扰 Rab 介导的多泡体运输，重新定向宿主细胞的营养，重建细胞内生态环境，来获得完成其细胞内发育周期所需的成分。因此，探讨囊泡运输在营养获取中的作用为预防和治疗 感染提供了一个新的视角。
