University of Wuerzburg, Biocenter, Department of Microbiology, Am Hubland, D-97074, Wuerzburg, Germany.
Cell Commun Signal. 2013 Nov 22;11:90. doi: 10.1186/1478-811X-11-90.
Modulation of host cell signaling and cellular functions is key to intracellular survival of pathogenic bacteria. Intracellular growth has several advantages e.g. escape from the humoral immune response and access to a stable nutrient rich environment. Growth in such a preferred niche comes at the price of an ongoing competition between the bacteria and the host as well as other microbes that compete for the very same host resources. This requires specialization and constant evolution of dedicated systems for adhesion, invasion and accommodation. Interestingly, obligate intracellular bacteria of the order Chlamydiales have evolved an impressive degree of control over several important host cell functions. In this review we summarize how Chlamydia controls its host cell with a special focus on signal transduction and cellular modulation.
宿主细胞信号转导和细胞功能的调节是致病菌在细胞内生存的关键。细胞内生长有几个优势，例如逃避体液免疫反应和获得稳定的富含营养的环境。在这样一个首选小生境中生长，细菌与宿主以及争夺宿主资源的其他微生物之间存在着持续的竞争。这需要专门化和不断进化用于黏附、入侵和适应的专用系统。有趣的是，衣原体纲的必需细胞内细菌已经进化出了对几种重要宿主细胞功能的令人印象深刻的控制程度。在这篇综述中，我们总结了衣原体如何控制其宿主细胞，特别关注信号转导和细胞调节。
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