Sharma Ujjawal, Sharma Bunty, Mishra Ambrish, Sahu Anidrisha, Mathkor Darin M, Haque Shafiul, Raina Deepika, Ramniwas Seema, Gupta Madhu, Tuli Hardeep S
Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda, India.
Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, India.
J Biochem Mol Toxicol. 2024 Jun;38(6):e23735. doi: 10.1002/jbt.23735.
Cancer is one of the major causes of death worldwide, with more than 10 million deaths annually. Despite tremendous advances in the health sciences, cancer continues to be a substantial global contributor to mortality. The current treatment methods demand a paradigm shift that not only improves therapeutic efficacy but also minimizes the side effects of conventional medications. Recently, an increased interest in the potential of natural bioactive compounds in the treatment of several types of cancer has been observed. Ononin, also referred to as formononetin-7-O-β-d-glucoside, is a natural isoflavone glycoside, derived from the roots, stems, and rhizomes of various plants. It exhibits a variety of pharmacological effects, including Antiangiogenic, anti-inflammatory, antiproliferative, proapoptotic, and antimetastatic activities. The current review presents a thorough overview of sources, chemistry, pharmacokinetics, and the role of ononin in affecting various mechanisms involved in cancer. The review also discusses potential synergistic interactions with other compounds and therapies. The combined synergistic effect of ononin with other compounds increased the efficacy of treatment methods. Finally, the safety studies, comprising both in vitro and in vivo assessments of ononin's anticancer activities, are described.
癌症是全球主要死因之一，每年有超过1000万人死于癌症。尽管健康科学取得了巨大进展，但癌症仍然是全球死亡率的重要原因。目前的治疗方法需要范式转变，不仅要提高治疗效果，还要尽量减少传统药物的副作用。最近，人们对天然生物活性化合物在治疗多种癌症方面的潜力越来越感兴趣。芒柄花苷，也被称为刺芒柄花素-7-O-β-D-葡萄糖苷，是一种天然异黄酮苷，来源于多种植物的根、茎和根茎。它具有多种药理作用，包括抗血管生成、抗炎、抗增殖、促凋亡和抗转移活性。本综述全面概述了芒柄花苷的来源、化学性质、药代动力学以及其在影响癌症相关各种机制中的作用。该综述还讨论了与其他化合物和疗法的潜在协同相互作用。芒柄花苷与其他化合物的联合协同作用提高了治疗方法的疗效。最后，描述了包括芒柄花苷抗癌活性的体外和体内评估在内的安全性研究。
