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从肠道到心脏:一例由胆囊炎诱发粪肠球菌菌血症所致感染性心内膜炎的病例报告

From Gut to Heart: A Case Report of Infectious Endocarditis Stemming From Cholecystitis-Induced Enterococcus faecium Bacteremia.

作者信息

Martinez-Esteban Alejandro, Barron-Cervantes Natalia M, Peña-Solorzano Sofia, Sierra-Lara Jorge-Daniel, Torruco-Sotelo Carlos, Faes-Petersen Regina, D G Gidi Alejandro, Villegas-Tovar Eduardo

机构信息

General and Gastrointestinal Surgery Service, Fundación Clínica Medica Sur, Mexico City, MEX.

General and Gastrointestinal Surgery Service, Fundación Clinica Médica Sur, Mexico City, MEX.

出版信息

Cureus. 2024 Apr 21;16(4):e58683. doi: 10.7759/cureus.58683. eCollection 2024 Apr.

DOI:10.7759/cureus.58683
PMID:38774161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11107479/
Abstract

Systemic infections are not always going to present as we expect. The study of bacteremia and febrile syndrome represents one of the most important diagnostic challenges nowadays. This case demonstrates the importance of a multidisciplinary approach and finding a common point that explains all the patient's symptoms, no matter how disconnected they may seem. Here, we present the case of a patient where multiple treatments were performed to manage recurrent infective endocarditis due to but the cause of this persistence was never found despite surgical management. With only a few cases reported in literature involving this pathogen, it is of great importance to emphasize how searching for a natural reservoir, such as the gallbladder, for this pathogen helped solve the diagnostic mystery that this patient represented. Here, we present how the culture of biological materials, such as the aortic valve replacement, as well as blood cultures, made it possible to identify the etiological agent associated with the pathology and, in turn, find the cause of recurrent bacteremia.

摘要

全身性感染并不总是如我们预期的那样表现出来。对菌血症和发热综合征的研究是当今最重要的诊断挑战之一。该病例表明了多学科方法的重要性,以及找到一个能解释患者所有症状的共同点的重要性,无论这些症状看起来多么不相关。在此,我们介绍一例患者的病例,该患者因[具体病因未提及]接受了多种治疗以处理复发性感染性心内膜炎,但尽管进行了手术治疗,仍未找到这种持续性感染的原因。鉴于文献中仅报道了少数涉及这种病原体的病例,强调寻找该病原体的自然储存库(如胆囊)如何帮助解开该患者所代表的诊断谜团非常重要。在此,我们展示了生物材料(如主动脉瓣置换物)的培养以及血培养如何能够识别与该病理相关的病原体,并进而找到复发性菌血症的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/5cea048dbbd6/cureus-0016-00000058683-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/6f949fd8fc22/cureus-0016-00000058683-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/7c6c129739dc/cureus-0016-00000058683-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/98849ed3da3a/cureus-0016-00000058683-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/cdead3397895/cureus-0016-00000058683-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/5cea048dbbd6/cureus-0016-00000058683-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/6f949fd8fc22/cureus-0016-00000058683-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/7c6c129739dc/cureus-0016-00000058683-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/98849ed3da3a/cureus-0016-00000058683-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/cdead3397895/cureus-0016-00000058683-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abd7/11107479/5cea048dbbd6/cureus-0016-00000058683-i05.jpg

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Antibiotic selection based on microbiology and resistance profiles of bile from gallbladder of patients with acute cholecystitis.基于急性胆囊炎患者胆汁的微生物学和耐药谱进行抗生素选择。
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Infective endocarditis.感染性心内膜炎。
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Gallbladder epithelium as a niche for chronic Salmonella carriage.胆囊上皮作为慢性沙门氏菌携带的生态位。
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Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage.胆石在沙门氏菌属胆囊定植和携带中起重要作用。
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Enterococcal surface protein Esp is important for biofilm formation of Enterococcus faecium E1162.肠球菌表面蛋白Esp对屎肠球菌E1162的生物膜形成很重要。
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Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study.感染性心内膜炎:流行病学变化及6个月死亡率的预测因素:一项前瞻性队列研究
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