Farsi Nasim Rahimi, Naghipour Bahman, Shahabi Parviz, Safaralizadeh Reza, Hajiasgharzadeh Khalil, Dastmalchi Narges, Alipour Mohammad Reza
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biology, University College of Nabi Akram, Tabriz, Iran.
Clin Exp Hepatol. 2023 Dec;9(4):307-319. doi: 10.5114/ceh.2023.131669. Epub 2023 Sep 28.
Hepatocellular carcinoma (HCC) is a severe malignant liver cancer with a poor prognosis and a high mortality rate. This carcinoma is a multistage process that begins with chronic hepatitis and progresses to cirrhosis, dysplastic nodules, and eventually HCC. However, the exact molecular etiology remains unclear. MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of numerous genes. These molecules have become significant participants in several functions, including cell proliferation, differentiation, development, and tumorrelated properties. They have a pivotal role in carcinogenesis as oncogenes or tumor suppressor genes. Furthermore, some investigations have shown that particular miRs might be used as predictive or diagnostic markers and therapeutic targets in HCC therapy. This review study summarizes the current level of knowledge on the role of miRs in the initiation and progression of HCC.
肝细胞癌（HCC）是一种严重的恶性肝癌，预后较差，死亡率高。这种癌症是一个多阶段过程，始于慢性肝炎，进而发展为肝硬化、发育异常结节，最终发展为肝细胞癌。然而，确切的分子病因仍不清楚。微小RNA（miRs）是调节众多基因表达的小非编码RNA。这些分子已成为细胞增殖、分化、发育和肿瘤相关特性等多种功能的重要参与者。它们作为癌基因或肿瘤抑制基因在致癌过程中起关键作用。此外，一些研究表明，特定的miRs可能用作肝细胞癌治疗中的预测或诊断标志物以及治疗靶点。本综述研究总结了目前关于miRs在肝细胞癌发生和发展中作用的知识水平。
