Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences , Mashhad, Iran.
University of South Florida College of Public Health , Tampa, FL, USA.
Cell Cycle. 2020 Dec;19(23):3209-3221. doi: 10.1080/15384101.2020.1843813. Epub 2020 Nov 9.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Sirtuins are NAD+-dependent histone deacetylases that regulate many cellular processes such as proliferation, apoptosis, and metabolism. SIRT (silent information regulator)-1, 5, 6 and 7, members of the mammalian Sirtuin family of proteins (SIRT1-SIRT7), are involved in carcinogenesis, prognosis, metastasis, and chemical resistant of HCC. These proteins act through the deacetylation of tumor suppressor or oncogenic factors. MicroRNAs (miRNAs) are a group of small non-coding RNAs that down regulate gene expression by targeting the 3'-untranslated region of miRNAs. MiRNAs can function as tumor suppressors or as oncogenes and are involved in progression, differentiation, apoptosis and drug resistance of tumor cells. The focus of this review is to delineate the relationship between some microRNAs and their target, Sirtuins, and to present an overview of their function in HCC as currently understood.
肝细胞癌（HCC）是最常见的原发性肝癌。沉默信息调节因子（Sirtuins）是依赖 NAD+的组蛋白去乙酰化酶，调节多种细胞过程，如增殖、凋亡和代谢。哺乳动物 Sirtuin 家族蛋白（SIRT1-SIRT7）的 SIRT（沉默信息调节）1、5、6 和 7 参与 HCC 的致癌作用、预后、转移和化学耐药性。这些蛋白质通过肿瘤抑制因子或致癌因子的去乙酰化作用发挥作用。微小 RNA（miRNAs）是一组小的非编码 RNA，通过靶向 miRNA 的 3'-非翻译区来下调基因表达。miRNAs 可以作为肿瘤抑制因子或癌基因发挥作用，并参与肿瘤细胞的进展、分化、凋亡和耐药性。本综述的重点是阐述一些 miRNA 与其靶标 Sirtuins 之间的关系，并概述它们在 HCC 中的作用。
