Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
APC Microbiome Ireland, University College Cork, Cork, Ireland.
Front Cell Infect Microbiol. 2024 May 7;14:1352267. doi: 10.3389/fcimb.2024.1352267. eCollection 2024.
Hypertensive disorders of pregnancy, including pre-eclampsia, are a leading cause of serious and debilitating complications that affect both the mother and the fetus. Despite the occurrence and the health implications of these disorders there is still relatively limited evidence on the molecular underpinnings of the pathophysiology. An area that has come to the fore with regard to its influence on health and disease is the microbiome. While there are several microbiome niches on and within the body, the distal end of the gut harbors the largest of these impacting on many different systems of the body including the central nervous system, the immune system, and the reproductive system. While the role of the microbiome in hypertensive disorders, including pre-eclampsia, has not been fully elucidated some studies have indicated that several of the symptoms of these disorders are linked to an altered gut microbiome. In this review, we examine both pre-eclampsia and microbiome literature to summarize the current knowledge on whether the microbiome drives the symptoms of pre-eclampsia or if the aberrant microbiome is a consequence of this condition. Despite the paucity of studies, obvious gut microbiome changes have been noted in women with pre-eclampsia and the individual symptoms associated with the condition. Yet further research is required to fully elucidate the role of the microbiome and the significance it plays in the development of the symptoms. Regardless of this, the literature highlights the potential for a microbiome targeted intervention such as dietary changes or prebiotic and probiotics to reduce the impact of some aspects of these disorders.
妊娠高血压疾病，包括子痫前期，是导致严重和使人衰弱的并发症的主要原因，这些并发症会影响母亲和胎儿。尽管这些疾病的发生及其对健康的影响已经得到了广泛的关注，但对于其病理生理学的分子基础，仍然存在相对有限的证据。一个在健康和疾病方面具有重要影响的领域是微生物组。虽然体内有几个微生物组生态位，但肠道的远端拥有最大的生态位，影响着身体的许多不同系统，包括中枢神经系统、免疫系统和生殖系统。虽然微生物组在妊娠高血压疾病（包括子痫前期）中的作用尚未完全阐明，但一些研究表明，这些疾病的一些症状与肠道微生物组的改变有关。在这篇综述中，我们检查了子痫前期和微生物组的文献，以总结目前关于微生物组是否导致子痫前期症状，或者异常微生物组是否是这种情况的结果的知识。尽管研究很少，但已经注意到子痫前期妇女的肠道微生物组发生了明显的变化，以及与这种情况相关的个体症状。然而，还需要进一步的研究来充分阐明微生物组的作用及其在症状发展中的重要性。尽管如此，文献强调了针对微生物组的干预措施的潜力，例如饮食改变或使用益生元和益生菌，以减轻这些疾病某些方面的影响。
