Parmesh Priyanka, Dinesh Udupi Shastri, Khandagale Ajay S, Bapu Anil Bargale, Sadashiv Roshni, Reddy Pradnya
Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Department of Laboratory Medicine, Victor hospital, Margao, Goa, India.
Arq Gastroenterol. 2024 May 20;61:e24016. doi: 10.1590/S0004-2803.24612024-016. eCollection 2024.
Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation. The existing biomarkers such as CEA (Carcinoembryonic antigen) etc., for prognosis, have low sensitivity and specificity. Hence a need for a newer definitive biomarker. Obesity is the leading cause of CRC. Leptin and adiponectin secreted by adipose tissue have been studied as potential biomarkers in the field of CRC. The present study helps to understand the association of leptin and adiponectin receptors with clinicopathological parameters.
To correlate the various clinicopathological parameters with the tissue expression of leptin and adiponectin receptors in CRC.
It is a cross-sectional prospective study conducted at a tertiary care hospital. Formalin fixed paraffin blocks of all radical resection CRC cases were collected and immunohistochemistry (IHC)was carried out on tumor tissue for leptin and adiponectin receptor. Tumor characteristics and clinical parameters were collected from the hospital medical records. Pearson's correlation coefficient test was used.
Immunohistochemistry was performed on 60 cases of CRC. Significant positive correlation of leptin was observed with size, lymph node metastasis, advanced stage, and grade of tumor (P<0.05). A significant correlation between adiponectin receptor and CRC was observed concerning age, stage, lymph node metastasis, distant metastasis and grade of tumor.
Positive expression of leptin and negative expression of adiponectin receptors in CRC helps to predict the risk of metastasis.
结直肠癌（CRC）是常见的癌症之一，由于其就诊时处于晚期，转移发生率不断上升。现有的用于预后的生物标志物，如癌胚抗原（CEA）等，敏感性和特异性较低。因此，需要一种更新的确定性生物标志物。肥胖是结直肠癌的主要病因。脂肪组织分泌的瘦素和脂联素已作为结直肠癌领域潜在的生物标志物进行了研究。本研究有助于了解瘦素和脂联素受体与临床病理参数的关联。
将各种临床病理参数与结直肠癌中瘦素和脂联素受体的组织表达进行关联分析。
这是一项在三级护理医院进行的横断面前瞻性研究。收集所有根治性切除的结直肠癌病例的福尔马林固定石蜡块，对肿瘤组织进行瘦素和脂联素受体的免疫组织化学（IHC）检测。从医院病历中收集肿瘤特征和临床参数。采用Pearson相关系数检验。
对60例结直肠癌病例进行了免疫组织化学检测。观察到瘦素与肿瘤大小、淋巴结转移、晚期及肿瘤分级呈显著正相关（P<0.05）。观察到脂联素受体与结直肠癌在年龄、分期、淋巴结转移、远处转移及肿瘤分级方面存在显著相关性。
结直肠癌中瘦素的阳性表达和脂联素受体的阴性表达有助于预测转移风险。
