Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Goudi, Athens, Greece.
Metabolism. 2011 Nov;60(11):1530-8. doi: 10.1016/j.metabol.2011.03.020. Epub 2011 May 31.
Adiponectin has been associated with colorectal cancer (CRC) risk. This study aims to investigate the association of both adiponectin and tissue expression of its receptors with CRC risk as well as clinicopathological characteristics, notably stage and grade. Determination of serum adiponectin and immunohistochemical expression of adiponectin receptors in adenocarcinoma/normal colorectal tissue was performed in samples from 104 newly diagnosed CRC patients and 208 age- and sex-matched controls. Multiple logistic regression odds ratios and 95% confidence intervals for CRC risk were derived, controlling for a series of covariates. Serum adiponectin was negatively associated with CRC risk (odds ratio, 0.72; confidence interval, 0.53-0.99) and also with tumor grade (P = .05). Expression of both adiponectin receptors was stronger in adenocarcinoma vs normal tissue (P = .001). AdipoR1 expression was negatively associated with nodal stage (P = .03); AdipoR2 expression was positively associated with tumor, node, metastasis stage (P = .01). Established positive associations with red meat consumption and diabetes, and negative associations with physical exercise and plant food consumption were confirmed along with a more than 60% higher risk associated with central obesity. Adiponectin levels and tissue expression of hormonal receptors seem to be associated not only with CRC risk but also with components of clinicopathological characteristics; given power limitations, these results should be interpreted with caution. The exact nature of the association and the underlying pathophysiological mechanisms need to be further examined in large prospective studies assessing adiponectin and its receptors as novel targets for exploring CRC growth.
脂联素与结直肠癌（CRC）风险相关。本研究旨在探讨脂联素及其受体的组织表达与 CRC 风险以及临床病理特征（尤其是分期和分级）的关系。在 104 例新诊断 CRC 患者和 208 例年龄和性别匹配的对照者的样本中，测定血清脂联素和其受体在腺癌/正常结直肠组织中的免疫组织化学表达。通过多因素逻辑回归比值比及其 95%置信区间，对 CRC 风险进行校正，控制一系列协变量。血清脂联素与 CRC 风险呈负相关（比值比，0.72；95%置信区间，0.53-0.99），与肿瘤分级也呈负相关（P =.05）。两种脂联素受体在腺癌与正常组织中的表达均较强（P =.001）。AdipoR1 表达与淋巴结分期呈负相关（P =.03）；AdipoR2 表达与肿瘤、淋巴结、转移分期呈正相关（P =.01）。与红肉消费和糖尿病呈正相关，与体育锻炼和植物性食物消费呈负相关的关联得到了证实，而中心性肥胖与 CRC 风险增加 60%以上有关。脂联素水平和激素受体的组织表达不仅与 CRC 风险相关，而且与临床病理特征的组成部分相关；由于存在统计学效能限制，这些结果应谨慎解读。需要进一步在评估脂联素及其受体作为探索 CRC 生长的新靶点的大型前瞻性研究中，进一步研究这种关联的性质和潜在的病理生理机制。
