Bogatskiĭ A V, Zaporozhan V N, Andronati S A, Khait O V, Litvinova L A
Eksp Onkol. 1985;7(5):64-5, 73.
The immune system state was studied before and after administration of tilorone (an immunologic adjuvant) to guinea pigs with synestrol-induced glandular hyperplasia of endometrium. The total amount of T- and B-lymphocytes. T-lymphocytes with receptors to the Fc-fragment of IgM and IgG, the content of immune complexes were determined. Immune and nonimmune adherence of neutrophils was investigated as well. It was established that the total amount of T-lymphocytes decreased and the quantity of T-lymphocytes and immune complexes increased with the development of glandular hyperplasia of the endometrium. The tilorone administration normalized the structure of endometrium and T-lymphocyte immune controlling system.
在给患有炔雌醇诱导的子宫内膜腺体增生的豚鼠施用泰洛龙（一种免疫佐剂）之前和之后，研究了其免疫系统状态。测定了T淋巴细胞和B淋巴细胞的总量、具有针对IgM和IgG的Fc片段受体的T淋巴细胞以及免疫复合物的含量。还研究了中性粒细胞的免疫和非免疫黏附情况。结果发现，随着子宫内膜腺体增生的发展，T淋巴细胞的总量减少，T淋巴细胞和免疫复合物的数量增加。施用泰洛龙使子宫内膜结构和T淋巴细胞免疫控制系统恢复正常。
