针对预先形成的可溶性登革热抗原-抗体复合物的正常人B淋巴细胞受体的体外研究。

In vitro studies of the normal human B lymphocyte receptors for preformed soluble dengue antigen-antibody complexes.

作者信息

Boonpucknavig S, Siripont J

出版信息

Clin Exp Immunol. 1980 Mar;39(3):676-82.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538136/

Abstract

Preformed soluble dengue antigen-antibody with or without complement complexes could bind to the surface of human lymphocytes via IgG (Fc) or complement receptors respectively. It may be that these lymphocytes were B lymphocytes not T lymphocytes. Dengue antigen or antibody alone will not attach to the surface of those cells. It is emphasized that dengue antigen-antibody complexes can form in the circulation and some will bind to the surface of the B lymphocytes in vivo and play a significant role in the pathogenesis of dengue haemorrhagic fever. In addition mice could develop glomerulonephritis by injection with preformed soluble dengue antigen-antibody complexes. These mice showed proteinuria and deposits of the immune complexes in the glomeruli of the kidneys.

摘要

预先形成的可溶性登革热抗原 - 抗体，无论有无补体复合物，都可分别通过IgG（Fc）或补体受体与人类淋巴细胞表面结合。这些淋巴细胞可能是B淋巴细胞而非T淋巴细胞。单独的登革热抗原或抗体不会附着于这些细胞表面。需要强调的是，登革热抗原 - 抗体复合物可在循环中形成，并且一些会在体内与B淋巴细胞表面结合，在登革出血热的发病机制中发挥重要作用。此外，通过注射预先形成的可溶性登革热抗原 - 抗体复合物，小鼠可发生肾小球肾炎。这些小鼠出现蛋白尿，且免疫复合物沉积于肾脏的肾小球中。

相似文献

1

In vitro studies of the normal human B lymphocyte receptors for preformed soluble dengue antigen-antibody complexes.针对预先形成的可溶性登革热抗原-抗体复合物的正常人B淋巴细胞受体的体外研究。

Clin Exp Immunol. 1980 Mar;39(3):676-82.

2

Human peripheral lymphocytes bearing surface immunoglobulin do not have readily detectable Fc receptors.带有表面免疫球蛋白的人外周淋巴细胞没有易于检测到的Fc受体。

Clin Exp Immunol. 1978 Aug;33(2):332-9.

3

Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other than Fc gamma receptors.由针对除Fcγ受体以外的细胞表面分子的双特异性抗体介导的登革病毒感染的抗体依赖性增强作用

J Immunol. 1991 Nov 1;147(9):3139-44.

4

Immunofluorescent staining of the surfaces of lymphocytes in suspension from patients with dengue hemorrhagic fever.登革出血热患者悬浮淋巴细胞表面的免疫荧光染色。

Am J Pathol. 1976 Oct;85(1):37-48.

5

Regulation and targeting of T-cell immune responses by IgE and IgG antibodies.IgE和IgG抗体对T细胞免疫反应的调节及靶向作用

Immunology. 1995 Nov;86(3):343-50.

6

Demonstration of dengue antibody complexes on the surface of platelets from patients with dengue hemorrhagic fever.登革出血热患者血小板表面登革热抗体复合物的证实。

Am J Trop Med Hyg. 1979 Sep;28(5):881-4.

7

Macrophage functions during dengue virus infection: antigenic stimulation of B cells.登革病毒感染期间巨噬细胞的功能：B细胞的抗原刺激

Immunology. 1987 Nov;62(3):493-8.

8

Immunological changes and recovery in patients with dengue haemorrhagic fever.登革出血热患者的免疫变化与恢复

Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):340-5.

9

Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8+ T cells in vivo.小鼠IgG的Fc受体在促进免疫复合物衍生抗原在体内呈递给CD8⁺T细胞的过程中具有冗余性。

Mol Immunol. 2006 May;43(13):2045-50. doi: 10.1016/j.molimm.2006.01.002. Epub 2006 Feb 28.

10

Circulating immune complexes in serum from patients with dengue haemorrhagic fever.登革出血热患者血清中的循环免疫复合物。

Clin Exp Immunol. 1979 Apr;36(1):46-53.

引用本文的文献

1

Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome?--a prospective cohort study.蛋白尿峰值能否预测登革热患者是否会发展为登革出血热/登革休克综合征？——一项前瞻性队列研究。

BMC Infect Dis. 2011 Aug 5;11:212. doi: 10.1186/1471-2334-11-212.

本文引用的文献

1

Partial purification and characterization of a dengue virus soluble complement-fixing antigen.登革病毒可溶性补体结合抗原的部分纯化及特性分析

J Immunol. 1970 Dec;105(6):1565-8.

2

Studies on passive serum sickness. I. The glomerular fine structure of serum sickness nephritis induced by preformed antigen-antibody complexes in the mouse.被动血清病研究。I. 小鼠中预先形成的抗原-抗体复合物诱导的血清病肾炎的肾小球精细结构

Lab Invest. 1971 May;24(5):383-91.

3

Studies of the human lymphocyte receptor for heat-aggregated or antigen-complexed immunoglobulin.人类淋巴细胞对热聚集或抗原复合免疫球蛋白受体的研究。

J Exp Med. 1974 Aug 1;140(2):508-22. doi: 10.1084/jem.140.2.508.

4

Mechanism of binding of soluble immune complexes to lymphocytes.可溶性免疫复合物与淋巴细胞结合的机制。

Cell Immunol. 1973 Jun;7(3):459-73. doi: 10.1016/0008-8749(73)90210-4.

5

Anti-dengue immunoglobulins and serum beta 1 c-a globulin levels in dengue shock syndrome.登革热休克综合征中的抗登革热免疫球蛋白及血清β1c-a球蛋白水平

J Immunol. 1969 Feb;102(2):412-20.

6

Binding of soluble immune complexes to human lymphoblastoid cells. II. Use of Raji cells to detect circulating immune complexes in animal and human sera.可溶性免疫复合物与人淋巴母细胞的结合。II. 利用拉吉细胞检测动物和人血清中的循环免疫复合物。

J Exp Med. 1974 Nov 1;140(5):1230-44. doi: 10.1084/jem.140.5.1230.

7

Indirect fluorescent antibody technic for demonstration of serum antibody in dengue hemorrhagic fever cases.用于登革出血热病例血清抗体检测的间接荧光抗体技术。

Am J Clin Pathol. 1975 Sep;64(3):365-71. doi: 10.1093/ajcp/64.3.365.

8

Immunoglobulin-bearing and complement-receptor lymphocytes constitute the same population in human peripheral blood.携带免疫球蛋白和补体受体的淋巴细胞在人类外周血中构成同一群体。

J Clin Invest. 1976 Jan;57(1):53-6. doi: 10.1172/JCI108268.

9

T and B lymphocytes in humans. A review.人类的T淋巴细胞和B淋巴细胞。综述。

Am J Pathol. 1975 Nov;81(2):446-58.

10

Interaction of human lymphocytes with fluid phase human C3b detected by immunofluorescence.通过免疫荧光检测人淋巴细胞与液相人C3b的相互作用。

Eur J Immunol. 1976 Jan;6(1):52-6. doi: 10.1002/eji.1830060111.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。