Boonpucknavig S, Siripont J
Clin Exp Immunol. 1980 Mar;39(3):676-82.
Preformed soluble dengue antigen-antibody with or without complement complexes could bind to the surface of human lymphocytes via IgG (Fc) or complement receptors respectively. It may be that these lymphocytes were B lymphocytes not T lymphocytes. Dengue antigen or antibody alone will not attach to the surface of those cells. It is emphasized that dengue antigen-antibody complexes can form in the circulation and some will bind to the surface of the B lymphocytes in vivo and play a significant role in the pathogenesis of dengue haemorrhagic fever. In addition mice could develop glomerulonephritis by injection with preformed soluble dengue antigen-antibody complexes. These mice showed proteinuria and deposits of the immune complexes in the glomeruli of the kidneys.
预先形成的可溶性登革热抗原 - 抗体，无论有无补体复合物，都可分别通过IgG（Fc）或补体受体与人类淋巴细胞表面结合。这些淋巴细胞可能是B淋巴细胞而非T淋巴细胞。单独的登革热抗原或抗体不会附着于这些细胞表面。需要强调的是，登革热抗原 - 抗体复合物可在循环中形成，并且一些会在体内与B淋巴细胞表面结合，在登革出血热的发病机制中发挥重要作用。此外，通过注射预先形成的可溶性登革热抗原 - 抗体复合物，小鼠可发生肾小球肾炎。这些小鼠出现蛋白尿，且免疫复合物沉积于肾脏的肾小球中。
