Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
PLoS One. 2024 May 22;19(5):e0303448. doi: 10.1371/journal.pone.0303448. eCollection 2024.
Individuals with type 1 diabetes (T1D) experience a complex set of alterations to skeletal muscle metabolic, neuromuscular, and vascular health; collectively referred to as diabetic myopathy. While the full scope of diabetic myopathy is still being elucidated, evidence suggests that even when individuals with T1D are physically active, indices of myopathy still exist. As such, there is a question if adherence to current physical activity guidelines elicits improvements in skeletal muscle health indices similarly between individuals with and without T1D. The objectives of this trial are to: 1) compare baseline differences in skeletal muscle health between adults with and without T1D, 2) examine the association between participation in a home-based exercise program, detraining, and retraining, with changes in skeletal muscle health, and 3) examine the roles of age and sex on these associations.
This will be a prospective interventional trial. Younger (18-30 years) and older (45-65 years) males and females with T1D and matched individuals without T1D will engage in a four-phase, 18-week study sequentially consisting of a one-week lead-in period, 12-week exercise training program, one-week detraining period, and four-week retraining period. The exercise program will consist of aerobic and resistance exercise based on current guidelines set by Diabetes Canada. Metabolic, neuromuscular, and vascular outcome measures will be assessed four times: at baseline, post-exercise program, post-detraining, and post-retraining. Differences in baseline metrics between those with and without T1D will be examined with independent sample t-tests, and with two-way analyses of variance for age- and sex-stratified analyses. Changes across the duration of the study will be examined using mixed-model analyses.
Findings from this research will be shared locally and internationally with research participants, clinicians, diabetes educators, and patient advocacy organizations via in-person presentations, social media, and scientific fora.
NCT05740514.
患有 1 型糖尿病（T1D）的个体经历一系列复杂的骨骼肌代谢、神经肌肉和血管健康改变；统称为糖尿病肌病。尽管糖尿病肌病的全貌仍在阐明中，但有证据表明，即使 T1D 个体进行身体活动，肌病的指标仍然存在。因此，人们质疑是否遵守当前的身体活动指南是否能在 T1D 患者和非 T1D 患者中同样改善骨骼肌健康指标。本试验的目的是：1）比较 T1D 患者和非 T1D 患者骨骼肌健康的基线差异，2）研究参与家庭锻炼计划、脱训和再训练与骨骼肌健康变化之间的关联，以及 3）研究年龄和性别对这些关联的作用。
这将是一项前瞻性干预试验。年轻（18-30 岁）和年长（45-65 岁）的男性和女性 T1D 患者和匹配的非 T1D 患者将按顺序进行四阶段、18 周的研究，包括为期一周的导入期、为期 12 周的运动训练计划、为期一周的脱训期和为期四周的再训练期。运动计划将包括基于加拿大糖尿病协会设定的当前指南的有氧运动和阻力运动。代谢、神经肌肉和血管结局测量将在四个时间点进行评估：基线时、运动方案后、脱训后和再训练后。使用独立样本 t 检验和年龄和性别分层分析的双因素方差分析来检查 T1D 患者和非 T1D 患者之间基线指标的差异。使用混合模型分析来检查研究期间的变化。
通过面对面演讲、社交媒体和科学论坛，将本研究的结果在本地和国际上与研究参与者、临床医生、糖尿病教育者和患者权益组织分享。
NCT05740514。
