Poznyak Anastasia V, Yakovlev Alexey A, Popov Mikhail А, Zhigmitova Elena B, Sukhorukov Vasily N, Orekhov Alexander N
Institute for Atherosclerosis Research, Moscow 121609, Russia.
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow 109240, Russia.
J Biomed Res. 2024 May 22;38(3):233-240. doi: 10.7555/JBR.37.20230198.
Atherosclerosis is extremely widespread. Traditionally, it is considered a disease of older people, who most often experience problems with the heart and blood vessels. While much attention from the scientific community has been paid to studying the association between aging and atherosclerosis, as well as its consequences, there is evidence that atherosclerosis occurs at an early age. Atherosclerosis may form both during intrauterine development and in childhood. Nutrition plays an important role in childhood atherosclerosis, along with previous infectious diseases and excess weight of both the child and the mother. In the present review, we examined the development of atherosclerosis and the prerequisites in childhood.
动脉粥样硬化极为普遍。传统上,它被认为是一种老年人的疾病,这些老年人最常出现心脏和血管方面的问题。虽然科学界已将大量注意力投入到研究衰老与动脉粥样硬化之间的关联及其后果,但有证据表明动脉粥样硬化在早年就会发生。动脉粥样硬化可能在子宫内发育期间和儿童期形成。营养在儿童动脉粥样硬化的发生过程中起着重要作用,同时还有既往感染性疾病以及儿童和母亲的超重问题。在本综述中,我们研究了儿童期动脉粥样硬化的发展情况及其先决条件。