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源自儿童期的动脉粥样硬化：特殊特征。

Atherosclerosis originating from childhood: Specific features.

作者信息

Poznyak Anastasia V, Yakovlev Alexey A, Popov Mikhail А, Zhigmitova Elena B, Sukhorukov Vasily N, Orekhov Alexander N

机构信息

Institute for Atherosclerosis Research, Moscow 121609, Russia.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow 109240, Russia.

出版信息

J Biomed Res. 2024 May 22;38(3):233-240. doi: 10.7555/JBR.37.20230198.

DOI:10.7555/JBR.37.20230198
PMID:38777340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144930/
Abstract

Atherosclerosis is extremely widespread. Traditionally, it is considered a disease of older people, who most often experience problems with the heart and blood vessels. While much attention from the scientific community has been paid to studying the association between aging and atherosclerosis, as well as its consequences, there is evidence that atherosclerosis occurs at an early age. Atherosclerosis may form both during intrauterine development and in childhood. Nutrition plays an important role in childhood atherosclerosis, along with previous infectious diseases and excess weight of both the child and the mother. In the present review, we examined the development of atherosclerosis and the prerequisites in childhood.

摘要

动脉粥样硬化极为普遍。传统上，它被认为是一种老年人的疾病，这些老年人最常出现心脏和血管方面的问题。虽然科学界已将大量注意力投入到研究衰老与动脉粥样硬化之间的关联及其后果，但有证据表明动脉粥样硬化在早年就会发生。动脉粥样硬化可能在子宫内发育期间和儿童期形成。营养在儿童动脉粥样硬化的发生过程中起着重要作用，同时还有既往感染性疾病以及儿童和母亲的超重问题。在本综述中，我们研究了儿童期动脉粥样硬化的发展情况及其先决条件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621e/11144930/9ebcdd041e82/jbr-38-3-233-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621e/11144930/8df353d56f9a/jbr-38-3-233-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621e/11144930/9ebcdd041e82/jbr-38-3-233-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621e/11144930/8df353d56f9a/jbr-38-3-233-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621e/11144930/9ebcdd041e82/jbr-38-3-233-2.jpg

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Wall shear stress and its role in atherosclerosis.壁面剪应力及其在动脉粥样硬化中的作用。
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Hyperlipidemia and Cardiovascular Risk in Children and Adolescents.儿童和青少年的高脂血症与心血管风险
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The Role of Inflammation in Cardiovascular Disease.炎症在心血管疾病中的作用。
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Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes.三酰甘油葡萄糖指数与无已知动脉粥样硬化性心血管疾病或糖尿病的患者的主动脉内中膜厚度独立相关。
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