Poznyak Anastasia V, Sukhorukov Vasily N, Surkova Raisa, Orekhov Nikolay A, Orekhov Alexander N
Institute for Atherosclerosis Research, Moscow, Russia.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia.
Front Cardiovasc Med. 2023 Jan 24;10:1094188. doi: 10.3389/fcvm.2023.1094188. eCollection 2023.
Atherosclerosis is a complex disease, and there are many factors that influence its development and the course of the disease. A deep understanding of the pathological mechanisms underlying atherogenesis is needed to develop optimal therapeutic strategies and treatments. In this review, we have focused on low density lipoproteins. According to multiple studies, their atherogenic properties are associated with multiple modifications of lipid particles. One of these modifications is Glycation. We considered aspects related to the formation of modified particles, as well as the influence of modification on their functioning. We paid special attention to atherogenicity and the role of glycated low-density lipoprotein (LDL) in atherosclerosis.
动脉粥样硬化是一种复杂的疾病，有许多因素会影响其发展和病程。要制定最佳的治疗策略和治疗方法，需要深入了解动脉粥样硬化发生的病理机制。在本综述中，我们重点关注了低密度脂蛋白。根据多项研究，它们的致动脉粥样硬化特性与脂质颗粒的多种修饰有关。其中一种修饰是糖基化。我们考虑了与修饰颗粒形成相关的方面，以及修饰对其功能的影响。我们特别关注了糖基化低密度脂蛋白（LDL）在动脉粥样硬化中的致动脉粥样硬化性及其作用。
