抗菌肽对细菌膜曲率的影响及反之亦然。

Influence of antimicrobial peptides on the bacterial membrane curvature and vice versa.

机构信息

S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, - MS, Brazil; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, - DF, Brazil; Instituto de Biociências, Universidade Federal de Mato Grosso do Sul, Campo Grande, - MS, Brazil.

Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Departments of Bioengineering and Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA; Penn Institute for Computational Science, University of Pennsylvania, Philadelphia, PA, USA; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA.

出版信息

Trends Microbiol. 2024 Jul;32(7):624-627. doi: 10.1016/j.tim.2024.04.012. Epub 2024 May 21.

DOI:10.1016/j.tim.2024.04.012

PMID:38777700

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11537279/

Abstract

Many factors contribute to bacterial membrane stabilization, including steric effects between lipids, membrane spontaneous curvature, and the difference in the number of neighboring molecules. This forum provides an overview of the physicochemical properties associated with membrane curvature and how this parameter can be tuned to design more effective antimicrobial peptides.

摘要

许多因素有助于细菌膜的稳定化，包括脂质之间的空间效应、膜的自发曲率以及相邻分子数量的差异。本论坛概述了与膜曲率相关的物理化学性质，以及如何调整该参数来设计更有效的抗菌肽。