Research and Development Center, INVICTA, Polna 64, 81-740, Sopot, Poland.
Department of Medical Biology and Genetics, University of Gdańsk, Gdańsk, Poland.
Sci Rep. 2024 May 22;14(1):11689. doi: 10.1038/s41598-024-61419-2.
We evaluated whether serum stem cell factor (s-SCF) levels just prior to ovulation induction could indicate the ability to develop a top-quality (TQ) blastocyst by day 5. We investigated patients with normal ovarian reserve (NOR), polycystic ovary syndrome (PCOS), diminished ovarian reserve (DOR), or mild endometriosis. Our pilot research suggests a correlation between s-SCF levels and the ability to form TQ blastocysts in patients with mild endometriosis. This significant statistical difference (p < 0.05) was noted between mild endometriosis patients for whom a TQ blastocyst was obtained and those for whom it was not possible, as measured on the 8th day of stimulation and the day of oocyte retrieval. The mean SCF levels in the serum of these women on the 8th day were at 28.07 (± 2.67) pg/ml for the TQ subgroup and 53.32 (± 16.02) pg/ml for the non-TQ subgroup (p < 0.05). On oocyte retrieval day it was 33.47 (± 3.93) pg/ml and 52.23 (± 9.72) pg/ml (p < 0.05), respectively.
我们评估了排卵诱导前的血清干细胞因子 (s-SCF) 水平是否可以预示在第 5 天形成优质囊胚 (TQ) 的能力。我们研究了具有正常卵巢储备 (NOR)、多囊卵巢综合征 (PCOS)、卵巢储备减少 (DOR) 或轻度子宫内膜异位症的患者。我们的初步研究表明，s-SCF 水平与轻度子宫内膜异位症患者形成 TQ 囊胚的能力之间存在相关性。在刺激的第 8 天和取卵日，在能够获得 TQ 囊胚的轻度子宫内膜异位症患者和不能获得 TQ 囊胚的患者之间，观察到显著的统计学差异 (p<0.05)。这些女性的血清中 SCF 水平在第 8 天分别为 TQ 亚组的 28.07(±2.67)pg/ml 和非 TQ 亚组的 53.32(±16.02)pg/ml (p<0.05)。在取卵日，分别为 33.47(±3.93)pg/ml 和 52.23(±9.72)pg/ml (p<0.05)。
