Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Clinical Epidemiology & EBM Unit, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China.
BMC Cancer. 2024 May 22;24(1):623. doi: 10.1186/s12885-024-12312-8.
We provided an overview which evaluated the diagnostic performance of circulation EV biomarkers for CRC from PubMed, Medline, and Web of Science until 21 August 2022.Weidentified 48 studies that involved 7727 participants and evaluated 162 plasma/serum individual EV biomarkers including 117 RNAs and 45 proteins, as well as 45 EV biomarker panels for CRC detection. 12 studies evaluated the diagnostic performance of EV biomarkers for early CRC. The summarized sensitivity, specificity, and AUC value of individual EV RNAs and EV RNA panels were 76%, 75%, 0.87 and 82%, 79% and 0.90, respectively. Meanwhile, those of individual EV proteins and EV protein panels were 85%, 84%, 0.92 and 87%, 83%, 0.92, respectively. These results indicated that EV biomarker panels revealed superior diagnostic performance than the corresponding individual biomarkers. In early CRC, EV biomarkers showed available diagnostic value with the sensitivity, specificity, and AUC value of 80%, 75%, and 0.89.In subgroup analyses, EV miRNAs and LncRNAs held similar diagnostic value with the sensitivity, specificity and AUC value of 75%, 78%, 0.90 and 79%, 72%, 0.83, which was highly consistent with the whole EV RNAs. Significantly, the diagnostic values of EV miRNAs in plasma were marginally higher than those based on serum. In detail, the sensitivity, specificity, and AUC values were 79%, 81%, and 0.92 in plasma, as well as 74%, 77%, and 0.88 in serum, respectively. Therefore, circulation EV biomarkers could be considered as a promising biomarker for the early detection of CRC.
我们提供了一个综述，评估了截至 2022 年 8 月 21 日从 PubMed、Medline 和 Web of Science 中循环 EV 生物标志物对 CRC 的诊断性能。我们确定了 48 项涉及 7727 名参与者的研究，并评估了 162 种血浆/血清个体 EV 生物标志物，包括 117 种 RNA 和 45 种蛋白质，以及 45 种用于 CRC 检测的 EV 生物标志物组合。12 项研究评估了 EV 生物标志物对早期 CRC 的诊断性能。个体 EV RNA 和 EV RNA 组合的汇总敏感性、特异性和 AUC 值分别为 76%、75%、0.87 和 82%、79%和 0.90。同时，个体 EV 蛋白和 EV 蛋白组合的敏感性、特异性和 AUC 值分别为 85%、84%、0.92 和 87%、83%、0.92。这些结果表明，EV 生物标志物组合比相应的个体生物标志物具有更好的诊断性能。在早期 CRC 中，EV 生物标志物具有较好的诊断价值，敏感性、特异性和 AUC 值分别为 80%、75%和 0.89。在亚组分析中，EV miRNAs 和 LncRNAs 具有相似的诊断价值，敏感性、特异性和 AUC 值分别为 75%、78%、0.90 和 79%、72%、0.83，与整个 EV RNA 高度一致。值得注意的是，EV miRNAs 在血浆中的诊断价值略高于血清。具体来说，血浆中的敏感性、特异性和 AUC 值分别为 79%、81%和 0.92，血清中分别为 74%、77%和 0.88。因此，循环 EV 生物标志物可以被认为是 CRC 早期检测的一种有前途的生物标志物。
