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使用 LuSy 剂量仪测定外照射放疗剂量的可行性。

Feasibility of determining external beam radiotherapy dose using LuSy dosimeter.

机构信息

Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Radiotherapy and Oncology Department, National Cancer Institute, Putrajaya, Malaysia.

出版信息

J Appl Clin Med Phys. 2024 Jun;25(6):e14387. doi: 10.1002/acm2.14387. Epub 2024 May 22.

Abstract

INTRODUCTION

Radiation dose measurement is an essential part of radiotherapy to verify the correct delivery of doses to patients and ensure patient safety. Recent advancements in radiotherapy technology have highlighted the need for fast and precise dosimeters. Technologies like FLASH radiotherapy and magnetic-resonance linear accelerators (MR-LINAC) demand dosimeters that can meet their unique requirements. One promising solution is the plastic scintillator-based dosimeter with high spatial resolution and real-time dose output. This study explores the feasibility of using the LuSy dosimeter, an in-house developed plastic scintillator dosimeter for dose verification across various radiotherapy techniques, including conformal radiotherapy (CRT), intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and stereotactic radiosurgery (SRS).

MATERIALS AND METHODS

A new dosimetry system, comprising a new plastic scintillator as the sensing material, was developed and characterized for radiotherapy beams. Treatment plans were created for conformal radiotherapy, IMRT, VMAT, and SRS and delivered to a phantom. LuSy dosimeter was used to measure the delivered dose for each plan on the surface of the phantom and inside the target volumes. Then, LuSy measurements were compared against an ionization chamber, MOSFET dosimeter, radiochromic films, and dose calculated using the treatment planning system (TPS).

RESULTS

For CRT, surface dose measurement by LuSy dosimeter showed a deviation of -5.5% and -5.4% for breast and abdomen treatment from the TPS, respectively. When measuring inside the target volume for IMRT, VMAT, and SRS, the LuSy dosimeter produced a mean deviation of -3.0% from the TPS. Surface dose measurement resulted in higher TPS discrepancies where the deviations for IMRT, VMAT, and SRS were -2.0%, -19.5%, and 16.1%, respectively.

CONCLUSION

The LuSy dosimeter was feasible for measuring radiotherapy doses for various treatment techniques. Treatment delivery verification enables early error detection, allowing for safe treatment delivery for radiotherapy patients.

摘要

简介

剂量测量是放射治疗的重要组成部分,可验证对患者的正确剂量输送并确保患者安全。放射治疗技术的最新进展突出了对快速和精确剂量计的需求。像 FLASH 放射治疗和磁共振线性加速器(MR-LINAC)等技术需要能够满足其独特要求的剂量计。一种有前途的解决方案是使用基于塑料闪烁体的剂量计,该剂量计具有高空间分辨率和实时剂量输出。本研究探索了使用 LuSy 剂量计(一种内部开发的塑料闪烁体剂量计)在各种放射治疗技术中进行剂量验证的可行性,包括适形放射治疗(CRT)、强度调制放射治疗(IMRT)、容积调强弧形治疗(VMAT)和立体定向放射外科(SRS)。

材料与方法

开发了一种新的剂量测量系统,包含一种新的塑料闪烁体作为传感材料,用于放射治疗束。为适形放射治疗、调强放射治疗、容积调强弧形治疗和立体定向放射外科创建了治疗计划,并将其输送到模体。使用 LuSy 剂量计在模体表面和靶区内部测量每个计划的传递剂量。然后,将 LuSy 测量值与电离室、MOSFET 剂量计、光致变色胶片和使用治疗计划系统(TPS)计算的剂量进行比较。

结果

对于 CRT,LuSy 剂量计测量的表面剂量分别比 TPS 低-5.5%和-5.4%,用于乳房和腹部治疗。当在 IMRT、VMAT 和 SRS 的靶区内进行测量时,LuSy 剂量计的 TPS 平均偏差为-3.0%。IMRT、VMAT 和 SRS 的表面剂量测量导致 TPS 偏差较大,分别为-2.0%、-19.5%和 16.1%。

结论

LuSy 剂量计可用于测量各种治疗技术的放射治疗剂量。治疗输送验证可实现早期错误检测,从而确保放射治疗患者的安全治疗输送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ffa/11163501/d5f0dce5718c/ACM2-25-e14387-g004.jpg

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