Chen S L, Xin J Y, Du M L, Wang M L
School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2024 May 25;27(5):447-451. doi: 10.3760/cma.j.cn441530-20240205-00058.
Globally, the incidence of early-onset colorectal cancer (EOCRC) among individuals younger than 50 is escalating. Compared to late-onset colorectal cancer, EOCRC exhibits distinct clinical, pathological, and molecular features, with a higher prevalence in the left colon and rectum. However, the occurrence and development of EOCRC is a multi-factor and multi-stage evolution process, which is the result of the mutual effect of environmental, genetic and biological factors, and involves the multi-level regulation mechanism of other organisms. With the development and improvement of high-throughput sequencing technology, the application of multi-omics analysis has become an important development direction to resolve the pathogenesis of complex diseases and individualized treatment plans. This article aims to review the research progress of EOCRC at the multi-omics level, providing a theoretical foundation for earlier diagnosis and more precise treatment of this diseases.
在全球范围内，50岁以下个体的早发性结直肠癌（EOCRC）发病率正在上升。与晚发性结直肠癌相比，EOCRC具有独特的临床、病理和分子特征，在左半结肠和直肠中的患病率更高。然而，EOCRC的发生和发展是一个多因素、多阶段的演变过程，是环境、遗传和生物学因素相互作用的结果，涉及其他生物体的多层次调控机制。随着高通量测序技术的发展和完善，多组学分析的应用已成为解决复杂疾病发病机制和制定个体化治疗方案的重要发展方向。本文旨在综述EOCRC在多组学水平上的研究进展，为该疾病的早期诊断和更精准治疗提供理论基础。
