Ajitbhai Garasiya A, Singh Prati P, Kumar Mukesh, Singh Rajinder, Dhiman Vandana
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali-160 062, Punjab, India.
Department of Pharmacy, Manav Bharti University, Solan, HP, India.
Malariaworld J. 2015 Mar 23;6:3. doi: 10.5281/zenodo.10870022. eCollection 2015.
Drug resistance has been one of the main obstacles in the fight against vector-borne infectious diseases. Among these diseases, malaria represents a serious public health challenge, mainly in the tropics, where vector-favourable climates are a crucial factor. Each of the various anti-malarial drugs currently used against this disease, such as quinolones, sulphonamides and artemisinins are inadequate and new strategies are required. Peptides are known to have a huge number of biological effects. Antimicrobial peptides (AMPs) have been proven to be effective against bacterial, fungal and viral infections. This study explored the effect of the peptide 'deltorphin-II' in infected mice.
Mean percentage parasitaemia was calculated by studying infected erythrocytes after microscopic examination of 10 erythrocytes from infected mice on days 4, 7, 10, 14 and 21 after infection in all groups. Deltorphin-II shows maximum activity at a dose of 0.8 mg/kg/day from day 4 to day 21. Pre-treatment of infected mice with naltriben abrogates the deltorphin-II-mediated effect.
Deltorphin-II inhibits the development of malaria, most probably via activation of the δ receptor.
耐药性一直是对抗媒介传播传染病的主要障碍之一。在这些疾病中，疟疾是一项严峻的公共卫生挑战，主要在热带地区，适宜媒介生存的气候是一个关键因素。目前用于治疗这种疾病的各种抗疟药物，如喹诺酮类、磺胺类和青蒿素类，都存在不足，因此需要新的策略。已知肽具有大量的生物学效应。抗菌肽（AMPs）已被证明对细菌、真菌和病毒感染有效。本研究探讨了肽“强啡肽 - II”对感染小鼠的影响。
通过在感染后第4、7、10、14和21天对所有组感染小鼠的10个红细胞进行显微镜检查，研究感染的红细胞，计算平均疟原虫血症百分比。从第4天到第21天，强啡肽 - II在剂量为0.8mg/kg/天时显示出最大活性。用纳曲本对感染小鼠进行预处理可消除强啡肽 - II介导的效应。
强啡肽 - II抑制疟疾的发展，很可能是通过激活δ受体实现的。
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