针对δ阿片受体的自身抗体发挥阿片类激动剂的作用，并表现出免疫调节活性。
Autoantibodies to the delta-opioid receptor function as opioid agonists and display immunomodulatory activity.
作者信息
Ranganathan Parvathi, Chen Hao, Adelman Miranda K, Schluter Samuel F
机构信息
Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, PO Box 245221, Tucson, Arizona 85724, USA.
出版信息
J Neuroimmunol. 2009 Dec 10;217(1-2):65-73. doi: 10.1016/j.jneuroim.2009.10.007. Epub 2009 Oct 30.
Abstract
In this report, we show that affinity purified human anti-delta opioid receptor (DOR) autoantibodies from IVIG are specific to DOR and possess agonistic properties displayed by their ability to dramatically decrease forskolin stimulated cAMP accumulation. Anti-DOR autoantibody also caused phosphorylation of the opioid receptor. Anti-DOR autoantibody treatment showed a significant reduction in CXCR4 gene expression as well as surface protein expression. In contrast, anti-DOR autoantibody treatment significantly upregulated CCR5 gene and protein expression. The presence of anti-DOR autoantibodies in IVIG and their potent immunomodulatory activity is further evidence to support the cross-talk between the neuroendocrine and immune systems.
摘要
在本报告中，我们表明，从静脉注射免疫球蛋白（IVIG）中亲和纯化得到的人抗δ阿片受体（DOR）自身抗体对DOR具有特异性，并具有激动特性，表现为它们能够显著降低福斯高林刺激的环磷酸腺苷（cAMP）积累。抗DOR自身抗体还导致阿片受体磷酸化。抗DOR自身抗体处理显示CXCR4基因表达以及表面蛋白表达显著降低。相比之下，抗DOR自身抗体处理显著上调CCR5基因和蛋白表达。IVIG中抗DOR自身抗体的存在及其强大的免疫调节活性进一步证明了神经内分泌系统与免疫系统之间存在相互作用。
相似文献
1
Autoantibodies to the delta-opioid receptor function as opioid agonists and display immunomodulatory activity.针对δ阿片受体的自身抗体发挥阿片类激动剂的作用，并表现出免疫调节活性。
J Neuroimmunol. 2009 Dec 10;217(1-2):65-73. doi: 10.1016/j.jneuroim.2009.10.007. Epub 2009 Oct 30.
2
Adenosine A(1) receptor agonist N(6)-cyclohexyl-adenosine induced phosphorylation of delta opioid receptor and desensitization of its signaling.腺苷 A(1)受体激动剂 N(6)-环已基-腺苷诱导 δ 阿片受体磷酸化和其信号转导脱敏。
Acta Pharmacol Sin. 2010 Jul;31(7):784-90. doi: 10.1038/aps.2010.70. Epub 2010 Jun 21.
3
Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.在中国仓鼠卵巢细胞中，稳定转染人δ-阿片受体后α-转导蛋白的表达减弱了慢性阿片类激动剂诱导的腺苷酸环化酶超活化。
Mol Pharmacol. 2001 Nov;60(5):1076-82. doi: 10.1124/mol.60.5.1076.
4
The effect of in vivo ethanol consumption on cyclic AMP and delta-opioid receptors in mouse striatum.体内乙醇摄入对小鼠纹状体中环磷酸腺苷（cAMP）和δ-阿片受体的影响。
Brain Res. 1997 Oct 3;770(1-2):65-71. doi: 10.1016/s0006-8993(97)00747-6.
5
Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors.在表达δ阿片受体的人胚肾细胞中阿片类配体的激活谱。
BMC Neurosci. 2002 Nov 18;3:19. doi: 10.1186/1471-2202-3-19.
6
Interleukin-1 beta-induced up-regulation of opioid receptors in the untreated and morphine-desensitized U87 MG human astrocytoma cells.白细胞介素-1β诱导未处理和吗啡脱敏的 U87 MG 人星形细胞瘤细胞中阿片受体的上调。
J Neuroinflammation. 2012 Nov 20;9:252. doi: 10.1186/1742-2094-9-252.
7
N-Desmethylclozapine, a major clozapine metabolite, acts as a selective and efficacious delta-opioid agonist at recombinant and native receptors.N-去甲基氯氮平是氯氮平的主要代谢产物，在重组受体和天然受体上作为一种选择性且有效的δ-阿片受体激动剂发挥作用。
Neuropsychopharmacology. 2007 Apr;32(4):773-85. doi: 10.1038/sj.npp.1301152. Epub 2006 Jul 12.
8
Effects of the altered activity of δ-opioid receptor on the expression of glutamate transporter type 3 induced by chronic exposure to morphine.慢性吗啡暴露诱导的谷氨酸转运体 3 表达变化中 δ 阿片受体活性改变的作用。
J Neurol Sci. 2013 Dec 15;335(1-2):174-81. doi: 10.1016/j.jns.2013.09.026. Epub 2013 Sep 25.
9
Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors.N-甲基-D-天冬氨酸受体的激活会减弱δ-阿片受体的急性反应性。
Mol Pharmacol. 1997 Apr;51(4):583-7. doi: 10.1124/mol.51.4.583.
10
Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes.三环类抗抑郁药对不同阿片受体亚型的直接激动作用。
J Pharmacol Exp Ther. 2010 Jan;332(1):255-65. doi: 10.1124/jpet.109.159939. Epub 2009 Oct 14.
引用本文的文献
1
Inhibitory effect of deltorphin-II on development of malaria in -infected mice.强啡肽-II对感染疟疾小鼠疟疾发展的抑制作用。
Malariaworld J. 2015 Mar 23;6:3. doi: 10.5281/zenodo.10870022. eCollection 2015.
2
Autoantibodies as Endogenous Modulators of GPCR Signaling.自身抗体作为 G 蛋白偶联受体信号转导的内源性调节剂。
Trends Pharmacol Sci. 2021 Mar;42(3):135-150. doi: 10.1016/j.tips.2020.11.013. Epub 2020 Dec 24.
3
Anti-Idiotypic Agonistic Antibodies: Candidates for the Role of Universal Remedy.抗独特型激动性抗体：通用治疗药物的候选者
Antibodies (Basel). 2020 May 28;9(2):19. doi: 10.3390/antib9020019.
4
T Cells as an Emerging Target for Chronic Pain Therapy.T细胞作为慢性疼痛治疗的新兴靶点。
Front Mol Neurosci. 2019 Sep 11;12:216. doi: 10.3389/fnmol.2019.00216. eCollection 2019.
5
Recent advances on the δ opioid receptor: from trafficking to function.δ阿片受体的最新进展：从转运到功能
Br J Pharmacol. 2015 Jan;172(2):403-19. doi: 10.1111/bph.12706. Epub 2014 Jul 1.
6
Opioid system and Alzheimer's disease.阿片系统与阿尔茨海默病。
Neuromolecular Med. 2012 Jun;14(2):91-111. doi: 10.1007/s12017-012-8180-3. Epub 2012 Apr 22.
本文引用的文献
1
Immunomodulation of human B cells following treatment with intravenous immunoglobulins involves increased phosphorylation of extracellular signal-regulated kinases 1 and 2.静脉注射免疫球蛋白治疗后人类B细胞的免疫调节涉及细胞外信号调节激酶1和2磷酸化增加。
Int Immunol. 2008 Nov;20(11):1369-79. doi: 10.1093/intimm/dxn090. Epub 2008 Aug 8.
2
Advances in the understanding of the mechanism of action of IVIg.静脉注射免疫球蛋白作用机制认识的进展
J Neurol. 2008 Jul;255 Suppl 3:3-6. doi: 10.1007/s00415-008-3002-0.
3
Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg).天然抗唾液酸结合免疫球蛋白样凝集素自身抗体介导潜在的免疫调节机制：对静脉注射免疫球蛋白（IVIg）临床应用的启示。
Autoimmun Rev. 2008 Jun;7(6):453-6. doi: 10.1016/j.autrev.2008.03.015. Epub 2008 Apr 18.
4
Role of natural antibodies in immune homeostasis: IVIg perspective.天然抗体在免疫稳态中的作用：静脉注射免疫球蛋白视角
Autoimmun Rev. 2008 Jun;7(6):440-4. doi: 10.1016/j.autrev.2008.04.011. Epub 2008 Apr 28.
5
What is the contents of the magic draft IVIg?神奇的IVIg（静脉注射免疫球蛋白）的成分是什么？
Autoimmun Rev. 2008 Jun;7(6):435-9. doi: 10.1016/j.autrev.2008.04.012. Epub 2008 May 2.
6
Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor.主要HIV-1共受体CXCR4与κ-阿片受体之间的双向异源脱敏
J Neuroimmunol. 2008 Jul 15;197(2):114-23. doi: 10.1016/j.jneuroim.2008.04.021. Epub 2008 Jun 3.
7
Delta opioid receptors mediate chemotaxis in bone marrow-derived dendritic cells.δ阿片受体介导骨髓来源树突状细胞的趋化作用。
J Neuroimmunol. 2008 Jun 15;197(1):21-8. doi: 10.1016/j.jneuroim.2008.03.020. Epub 2008 May 16.
8
Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?阿片类药物与趋化因子受体异二聚体：是包办婚姻还是危险关系？
Biochem J. 2008 Jun 1;412(2):e7-9. doi: 10.1042/BJ20080620.
9
Infection of macrophages and dendritic cells with primary R5-tropic human immunodeficiency virus type 1 inhibited by natural polyreactive anti-CCR5 antibodies purified from cervicovaginal secretions.从宫颈阴道分泌物中纯化的天然多反应性抗CCR5抗体可抑制巨噬细胞和树突状细胞被原发性R5嗜性1型人类免疫缺陷病毒感染。
Clin Vaccine Immunol. 2008 May;15(5):872-84. doi: 10.1128/CVI.00463-07. Epub 2008 Mar 19.
10
Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression.阿片受体和孤啡肽受体调节细胞因子及细胞因子受体的表达。
Cell Immunol. 2008 Mar-Apr;252(1-2):146-54. doi: 10.1016/j.cellimm.2007.09.008. Epub 2008 Feb 14.
Zotero 插件