Department of Medicine, Qingdao University, Qingdao, China.
Department of Rehabilitation Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Front Immunol. 2024 May 8;15:1407439. doi: 10.3389/fimmu.2024.1407439. eCollection 2024.
Increasing evidence indicates the microbial ecology of chronic obstructive pulmonary disease (COPD) is intricately associated with the disease's status and severity, and distinct microbial ecological variations exist between COPD and healthy control (HC). This systematic review and meta-analysis aimed to summarize microbial diversity indices and taxa relative abundance of oral, airway, and intestine microbiota of different stages of COPD and HC to make comparisons.
A comprehensive systematic literature search was conducted in PubMed, Embase, the Web of Science, and the Cochrane Library databases to identify relevant English articles on the oral, airway, and intestine microbiota in COPD published between 2003 and 8 May 2023. Information on microbial diversity indices and taxa relative abundance of oral, airway, and intestine microbiota was collected for comparison between different stages of COPD and HC.
A total of 20 studies were included in this review, involving a total of 337 HC participants, 511 COPD patients, and 154 AECOPD patients. We observed that no significant differences in alpha diversity between the participant groups, but beta diversity was significantly different in half of the included studies. Compared to HC, , , , and of oral microbiota in SCOPD were reduced at the genus level. Most studies supported that , , and were increased, but , , , , and were decreased at the genus level in the airway microbiota of SCOPD. However, the abundance of , and genera exhibited an increase, whereas and showed a decrease in the airway microbiota of AECOPD compared to HC. And of intestine microbiota in SCOPD was reduced at the genus level.
The majority of published research findings supported that COPD exhibited decreased alpha diversity compared to HC. However, our meta-analysis does not confirm it. In order to further investigate the characteristics and mechanisms of microbiome in the oral-airway- intestine axis of COPD patients, larger-scale and more rigorous studies are needed.
PROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42023418726.
越来越多的证据表明，慢性阻塞性肺疾病（COPD）的微生物生态学与疾病的状态和严重程度密切相关，COPD 和健康对照组（HC）之间存在明显的微生物生态差异。本系统评价和荟萃分析旨在总结 COPD 不同阶段和 HC 的口腔、气道和肠道微生物群的微生物多样性指数和分类相对丰度，以进行比较。
在 PubMed、Embase、Web of Science 和 Cochrane Library 数据库中进行全面的系统文献检索，以确定 2003 年至 2023 年 5 月 8 日期间发表的关于 COPD 口腔、气道和肠道微生物群的相关英文文章。收集口腔、气道和肠道微生物群的微生物多样性指数和分类相对丰度信息，以比较 COPD 不同阶段和 HC 之间的差异。
本综述共纳入 20 项研究，共涉及 337 名 HC 参与者、511 名 COPD 患者和 154 名 AECOPD 患者。我们观察到，参与者组之间的 alpha 多样性没有显著差异，但在一半的纳入研究中，beta 多样性存在显著差异。与 HC 相比，SCOPD 患者的口腔微生物群在属水平上， 、 、 和 减少。大多数研究支持 SCOPD 患者的气道微生物群中 、 、 和 增加，但 、 、 、 和 减少。然而，AECOPD 患者的气道微生物群中 、 和 属的丰度增加，而 、 和 属的丰度减少。SCOPD 患者的肠道微生物群在属水平上减少 。
大多数已发表的研究结果支持 COPD 患者的 alpha 多样性与 HC 相比降低。然而，我们的荟萃分析并不能证实这一点。为了进一步研究 COPD 患者口腔-气道-肠道轴微生物组的特征和机制，需要进行更大规模和更严格的研究。
PROSPERO（https://www.crd.york.ac.uk/prospero/），标识符 CRD42023418726。
