Wu Shijie, Wu Kun, Yang Yuqing, Ou Zhiwen, Lei Xiaoyong, Yang Xiaoyan
School of Pharmacy, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan, 421001, P.R. China.
Chuanshan College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan, 421001, People's Republic of China.
Curr Mol Med. 2025;25(6):686-696. doi: 10.2174/0115665240298173240427042624.
As lncRNAs have increasingly been investigated, they are no longer simply defined as RNAs with no transcription capability. Studies have identified significant associations between the abnormal expression of lncRNAs and human diseases, particularly the mechanisms by which lncRNAs play a part in cancers, which are of considerable attention to researchers. As a result of the complex spatial structure, the mechanisms of interaction of lncRNAs in cancer cells are also complicated and diversified. Among a series of lncRNAs, TUG1, which is now considered to be a very high-value lncRNA, has recently been identified to express abnormally in some malignancies, leading to different alterations in cancer cells proliferation, migration, invasion, apoptosis, and drug resistance, and hence promoting or inhibiting cancer progression. Current studies have implicitly indicated that TUG1 can be used as a therapeutic target for human cancers. However, the biological functions of TUG1 have been studied for a short period of time, and the complete molecular mechanism still needs to be clarified. Accordingly, this review focuses on the principal molecular mechanisms of TUG1 in human cancers and the specific mechanisms of action in different cancer development processes based on existing studies.
随着长链非编码RNA（lncRNAs）受到越来越多的研究，它们不再仅仅被定义为没有转录能力的RNA。研究已经确定lncRNAs的异常表达与人类疾病之间存在显著关联，特别是lncRNAs在癌症中发挥作用的机制，这受到了研究人员的广泛关注。由于其复杂的空间结构，lncRNAs在癌细胞中的相互作用机制也复杂多样。在一系列lncRNAs中，TUG1目前被认为是一种具有很高价值的lncRNA，最近已被发现在一些恶性肿瘤中异常表达，导致癌细胞增殖、迁移、侵袭、凋亡和耐药性发生不同改变，从而促进或抑制癌症进展。目前的研究已暗示TUG1可作为人类癌症的治疗靶点。然而，TUG1的生物学功能研究时间较短，完整的分子机制仍有待阐明。因此，本综述基于现有研究，聚焦于TUG1在人类癌症中的主要分子机制以及在不同癌症发展过程中的具体作用机制。
