Azizidoost Shirin, Nasrolahi Ava, Ghaedrahmati Farhoodeh, Kempisty Bartosz, Mozdziak Paul, Radoszkiewicz Klaudia, Farzaneh Maryam
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cancer Cell Int. 2022 Nov 4;22(1):335. doi: 10.1186/s12935-022-02745-1.
Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although various conventional methods have been used for the treatment of patients with CRC, the early detection and identification of molecular mechanisms associated with CRC is necessary. The scientific literature reports that altered expression of long non-coding RNAs (lncRNAs) contributed to the pathogenesis of CRC cells. LncRNA TUG1 was reported to target various miRNAs and signaling pathways to mediate CRC cell proliferation, migration, and metastasis. Therefore, TUG1 might be a potent predictive/prognostic biomarker for diagnosis of CRC.
结直肠癌（CRC）是一种起源于结肠、直肠或阑尾的胃肠道肿瘤。CRC患者，尤其是那些有转移病灶的患者，其预后仍不尽人意。尽管已采用各种传统方法治疗CRC患者，但仍有必要早期检测并识别与CRC相关的分子机制。科学文献报道，长链非编码RNA（lncRNA）表达改变促成了CRC细胞的发病机制。据报道，LncRNA TUG1靶向多种微小RNA（miRNA）和信号通路，以介导CRC细胞的增殖、迁移和转移。因此，TUG1可能是诊断CRC的一种有效的预测/预后生物标志物。
