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健康对照中的免疫球蛋白:HLA - B8与性别差异。

Immunoglobulins in healthy controls: HLA-B8 and sex differences.

作者信息

Cryan E M, Stevens F M, Skehill R, Bourke M, Grimes H, McCarthy C F

出版信息

Tissue Antigens. 1985 Oct;26(4):254-8. doi: 10.1111/j.1399-0039.1985.tb00968.x.

DOI:10.1111/j.1399-0039.1985.tb00968.x
PMID:3878013
Abstract

Serum immunoglobulins were measured in one hundred and eighty-four healthy controls. One hundred and fifty-nine of these were also HLA typed. IgG levels did not differ with sex or HLA-B8 status. IgM levels did not differ with HLA-B8 status but were significantly higher in females than males. IgA levels were lower in females than males; they were also lower in HLA-B8 positive compared with HLA-B8 negative individuals; the lowest IgA levels were found in HLA-B8 positive females. The IgA variation may be relevant to the higher incidence of certain disorders among HLA-B8 positive individuals and among females.

摘要

对184名健康对照者测定了血清免疫球蛋白。其中159人还进行了HLA分型。IgG水平在性别或HLA - B8状态方面没有差异。IgM水平在HLA - B8状态方面没有差异,但女性显著高于男性。女性的IgA水平低于男性;与HLA - B8阴性个体相比,HLA - B8阳性个体的IgA水平也较低;HLA - B8阳性女性的IgA水平最低。IgA的变化可能与HLA - B8阳性个体和女性中某些疾病的较高发病率有关。

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