Frick M H, Harjola P T, Valle M
Acta Med Scand Suppl. 1985;701:148-54. doi: 10.1111/j.0954-6820.1985.tb08899.x.
The effects of coronary bypass surgery on morbidity, mortality and employment were assessed in a randomized prospective 5-year study. Exercise tolerance showed an immediate, striking improvement, which was maintained throughout the follow-up period. Corresponding patients treated with medical therapy showed no change. More than 40 percent of patients in the surgical group were free from symptoms over the five years. The annual mortality of the surgical patients was 0.8 percent as compared with 4.0 percent in the medical patients (p less than 0.05). The annual mortality of the intensively treated medical patients with multivessel disease was not significantly higher than the 3.1 percent for a group of patients with single-vessel disease followed concomitantly. The rate of work at 5 years after bypass surgery was 47 percent as compared with only 18 percent in the randomized medically treated group (p less than 0.01). It is concluded that coronary bypass surgery reduces morbidity and mortality and improves employment.
在一项随机前瞻性5年研究中，评估了冠状动脉搭桥手术对发病率、死亡率和就业情况的影响。运动耐量立即有显著改善，并在整个随访期内得以维持。接受药物治疗的相应患者则无变化。手术组超过40%的患者在五年内无症状。手术患者的年死亡率为0.8%，而药物治疗患者为4.0%（p<0.05）。多支血管病变且接受强化治疗的药物治疗患者的年死亡率并不显著高于同期随访的单支血管病变患者组的3.1%。搭桥手术后5年的工作率为47%，而随机接受药物治疗组仅为18%（p<0.01）。结论是冠状动脉搭桥手术可降低发病率和死亡率，并改善就业情况。
