Davies M, Mawer E B, Hann J T, Stephens W P, Taylor J L
Age Ageing. 1985 Nov;14(6):349-54. doi: 10.1093/ageing/14.6.349.
A comparison of two regimens of vitamin D prophylaxis in elderly institutionalized subjects has been made. Sixty-six subjects received 2.5mg vitamin D2 by mouth in December 1982; a further group of 62 received the same dose in December 1982 and again in June 1983. Blood samples have been analysed for 25-hydroxyvitamin D2 [25(OH)D2] in 10 subjects from each group over a 12-month period. The serum 25(OH)D2 was maintained at normal concentrations for most of the year in the once-a-year dosage group but at the end of 12 months only 60% were fully protected. The twice-per-year regimen offered complete protection maintaining the serum 25(OH)D2 above the threshold associated with osteomalacia. It is concluded that a twice-yearly regimen of vitamin D supplementation is a practical method for prophylaxis in institutionalized elderly people.
对老年住院患者两种维生素D预防方案进行了比较。66名受试者于1982年12月口服2.5mg维生素D2；另一组62名受试者于1982年12月接受相同剂量，并于1983年6月再次接受该剂量。在12个月期间，对每组10名受试者的血样进行了25-羟维生素D2 [25(OH)D2]分析。在每年给药一次的组中，血清25(OH)D2在一年中的大部分时间保持在正常浓度，但在12个月末只有60%的人得到充分保护。每年给药两次的方案提供了完全保护，使血清25(OH)D2保持在与骨软化症相关的阈值以上。结论是，每年两次补充维生素D的方案是预防老年住院患者的一种实用方法。
