Department of General Pediatrics, Trousseau Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France.
Dental Faculty, Rothschild Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Universite Paris Cite, Paris, France.
Eur J Clin Microbiol Infect Dis. 2024 Jul;43(7):1487-1493. doi: 10.1007/s10096-024-04853-4. Epub 2024 May 23.
Aggregatibacter actinomycetemcomitans (Aa), a Gram-negative coccobacillus commonly associated with endocarditis, poses a rare diagnostic challenge in pediatric cases. The presentation of two pediatric cases-myositis and chest mass-highlights novel aspects, including unusual symptom presentations in children which can be mistaken for malignancy. The limited sensitivity of standard blood tests complicates diagnosis, leading to delayed diagnosis and treatment. Representative samples must be taken, especially if blood cultures are negative. Despite advances in detection methods, diagnosing Aa infection remains difficult due to its rarity in children and variable clinical presentation. In conclusion, a comprehensive understanding of Aa infection in children is essential for early and effective diagnostic and therapeutic management.
伴放线放线杆菌（Aa），一种常见的革兰氏阴性球杆菌，通常与心内膜炎有关，在儿科病例中构成了罕见的诊断挑战。两个儿科病例-肌炎和胸腔肿块-的表现突出了新的方面，包括儿童中不常见的症状表现，这些症状可能被误诊为恶性肿瘤。标准血液检测的有限敏感性使诊断变得复杂，导致诊断和治疗延迟。必须采集代表性样本，尤其是如果血培养为阴性。尽管检测方法有所进步，但由于儿童中 Aa 感染的罕见性和不同的临床表现，诊断 Aa 感染仍然具有挑战性。总之，全面了解儿童中的 Aa 感染对于早期和有效的诊断和治疗管理至关重要。
