Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China.
Curr Hypertens Rep. 2024 Jul;26(7):325-337. doi: 10.1007/s11906-024-01306-3. Epub 2024 May 23.
Pregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.
Of 2550 publications identified, 23 studies were included. The meta-analysis indicated that preeclampsia increases the potential risk of hypertension in offspring. Systolic blood pressure (SBP) was 2.0 mm Hg (95% CI: 1.2, 2.8) and diastolic blood pressure (DBP) was 1.4 mm Hg (95% CI: 0.9, 1.9) higher in offspring exposed to pre-eclampsia in utero, compared to those born to normotensive mothers. The correlations were similar in stratified analyses of children and adolescents by sex, geographic area, ages, and gestational age. During childhood and young adulthood, the offspring of pregnant women with preeclampsia are at an increased risk of high BP. It is crucial to monitor their BP.
妊娠诱发的子痫前期是一种严重的妊娠并发症，子痫前期与后代发生慢性高血压的风险增加有关。然而，暴露于妊娠子痫前期对后代血压（BP）的总体影响的程度尚不清楚。本系统评价和荟萃分析旨在系统评估子痫前期对子代 BP 的影响。
在确定的 2550 篇文献中，有 23 项研究被纳入。荟萃分析表明，子痫前期增加了后代发生高血压的潜在风险。与正常血压母亲所生的后代相比，宫内暴露于子痫前期的后代收缩压（SBP）高 2.0mmHg（95%CI：1.2，2.8），舒张压（DBP）高 1.4mmHg（95%CI：0.9，1.9）。在按性别、地理区域、年龄和胎龄对儿童和青少年进行的分层分析中，相关性相似。在儿童期和成年早期，患有子痫前期的孕妇的后代患高血压的风险增加。监测他们的血压非常重要。
